ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020
Linitis Plastica: a Distinct Type of Gastric Cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 29 citations in OpenAlex.
- Pattern of lymph node spread in gastric cancer: Western multicenter retrospective study.BJS open · 2026Article
- Article
- Linitis Plastica-like Metastases to the Gastrointestinal Tract on Cross-Sectional Imaging.Biomedicines · 2025Review
- Therapeutic strategies and prognostic challenges in linitis plastica.World journal of experimental medicine · 2025Article
- Cold snaring biopsies to increase screening efficacy during endoscopic surveillance of patients at high risk of diffuse gastric cancer.Endoscopy · 2024Article
- Perioperative chemotherapy improves survival of patients with locally advanced diffuse gastric cancer.World journal of gastrointestinal surgery · 2024Article
- A rare cause of progressive dysphagia.Clinical endoscopy · 2024Article
- Cytoreduction and Hyperthermic Intraperitoneal Paclitaxel and Cisplatin for Gastric Cancer with Peritoneal Metastasis.Annals of surgical oncology · 2024Article
- The Genomic Signatures of Linitis Plastica Signal the Entrance into a New Era: Novel Approaches for Diagnosis and Treatment.International journal of molecular sciences · 2023Review
- Borrmann Type Predicts Response to Preoperative Therapy in Advanced Gastric Cancer.Journal of gastrointestinal cancer · 2023Article
- Clinical Impact of Positive Surgical Margins in Gastric Adenocarcinoma in the Era of Preoperative Therapy.Annals of surgical oncology · 2023Article
- Primary gastric amyloidosis associated with linitis plastica and delayed progression to systemic amyloidosis and multiple myeloma.BMJ case reports · 2023Article
- Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Gastric adenocarcinoma peritoneal carcinomatosis: a narrative review.Digestive medicine research · 2022Article
- Prediction of epithelial-to-mesenchymal transition molecular subtype using CT in gastric cancer.European radiology · 2022Article
- Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research.BMC gastroenterology · 2021Article
- Prognosis prediction model for a special entity of gastric cancer, linitis plastica.Journal of gastrointestinal oncology · 2021Article
- Development of a Quantitative Diagnostic Criterion for Gastric Linitis Plastica: Findings From a Large Single-Institutional Study.Frontiers in oncology · 2021Article
- Short-term and long-term survival of patients with gastric cancer.Gastroenterology and hepatology from bed to bench · 2021Article
- The efficacy of treating patients with non-metastatic gastric linitis plastica using surgery with chemotherapy and/or radiotherapy.Annals of translational medicine · 2020Article
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Authors and funding
11 authors at 1 institution in 1 country.
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Abstract
backgroundThe prognosis of patients with linitis plastica (LP) gastric cancer is reported to be poor. The purpose of our retrospective study was to characterize the clinicopathologic features and survival outcomes of patients with LP, using a univocal definition.
methodsWe defined LP as gastric cancer that involves more than 1/3 of the gastric wall macroscopically. We reviewed a prospectively maintained institutional database of gastric cancer patients and summarized and compared clinicopathologic factors of patients with and without LP who had undergone gastrectomy. Patients were matched 1:1 using propensity score matching, and their overall survival (OS) rates and durations were compared. Multivariable Cox regression analyses were conducted, using gastrectomy as a time-varying covariate.
resultsWe identified 740 patients with radiographically non-metastatic gastric cancer, 157 (21.2%) of whom had LP. Most patients with LP had advanced-stage disease (75.8% had stage IV disease, mainly due to peritoneal involvement). Patients with LP had significantly shorter OS durations than did those without LP in the entire cohort (median OS, 14.0 vs. 33.5 months; p value < 0.001) and in the surgical cohort (median OS after gastrectomy, 21.8 vs. 91.0 months; p < 0.001), as well as in the propensity-matched surgical cohort. In the LP cohort, chemotherapy (hazard ratio [HR] = 0.594; p = 0.076), chemoradiation therapy (HR = 0.346; p = 0.001), and gastrectomy (HR = 0.425; p = 0.003) were associated with a longer OS.
conclusionsLP is a phenotype of gastric cancer that often presents at an advanced stage, with a high rate of peritoneal involvement. The survival durations of patients with LP were poor in our study, even in the surgical cohort. The use of preoperative chemotherapy, chemoradiation therapy, and gastrectomy appeared to be important in carefully selected patients with localized LP.
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