Evidence map›Paper›PMID 31754951›Full record

ArticleBreast cancer research and treatment2020

Results of a phase I, non-randomized study evaluating a Magnetic Occult Lesion Localization Instrument (MOLLI) for excision of non-palpable breast lesions.

Nicole Look Hong, Frances C Wright, Mark Semple, Alexandru M Nicolae, Ananth Ravi

2 registry-linked trialsAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04893421 nacompletednot on this mapstarted 2021, after this paper: background citation

A Registry Study Evaluating the Magnetic Occult Lesion Localization Instrument (MOLLI) Guidance System for Breast Lesion Localization

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2021 to 2024Enrolled41ConditionsBreast NeoplasmArmsMOLLI Localization
NCT07131735 recruitingnot on this mapstarted 2023, after this paper: background citation

Intraoperative Detection of Breast Cancer by Electrosurgical Gas Analysis and Artificial Intelligence

Typeobservational_patient_registrySponsorPontificia Universidad Catolica de ChileRan2023 to 2025Enrolled30ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole Look HongDepartment of Surgery, Sunnybrook Odette Cancer Centre, Toronto, ON, M4N-3M5, Canada.
Frances C WrightDepartment of Surgery, Sunnybrook Odette Cancer Centre, Toronto, ON, M4N-3M5, Canada.
Mark SempleDepartment of Medical Physics, Sunnybrook Odette Cancer Centre, 2075 Bayview Ave, Toronto, ON, M4N-3M5, Canada.
Alexandru M NicolaeClinical Research Program, Sunnybrook Research Institute, Toronto, ON, M4N-3M5, Canada.
Ananth RaviDepartment of Medical Physics, Sunnybrook Odette Cancer Centre, 2075 Bayview Ave, Toronto, ON, M4N-3M5, Canada. ananth.ravi@sunnybrook.ca.ORCID http://orcid.org/0000-0003-4583-5741

Funding

Canadian Cancer Society Research Institute 705239
6 · The paper itself

Abstract

purposeMagnetic Occult Lesion Localization Instrument (MOLLI) is a wireless, non-radioactive alternative for non-palpable breast lesion localization. The primary objective of this first-in-human study was to evaluate the clinical feasibility of using MOLLI for intraoperative localization of non-palpable breast lesions.

methodsTwenty women with non-palpable breast lesions at a single institution received a lumpectomy using the MOLLI guidance system. Patients were co-localized with magnetic and radioactive markers up to 7 days before excision by a dedicated breast radiologist under sonographic guidance. Both markers were localized intraoperatively using dedicated hand-held probes. The primary outcome was successful excision of the magnetic marker, confirmed radiographically and pathologically. Demographic data, margin positivity, and re-excision rates were collected. Surgical oncologists, radiologists, and pathology staff were surveyed for user satisfaction.

resultsPost-radiological analysis: Post-implant mammograms verified that 17/20 markers were placed directly in the lesion center. Radiologists reported that all marker implantations procedures were "easy" or "very easy" following a single training session. Post-surgical analysis: All MOLLI markers were successfully removed with the specimen during surgical excision. In all cases, surgeons ranked the MOLLI guidance system as "very easy" for lesion localization. Pathologic analysis: All patients had negative margins. All anatomic pathology staff ranked the MOLLI system as "very easy" to localize markers.

conclusionsThe MOLLI guidance system is a reliable and accurate method for intraoperative localization of non-palpable breast lesions. Further evaluation of the MOLLI system in studies against current standards of care is required to demonstrate system cost-effectiveness and improved patient-reported outcomes.

Indexed as

AgedBreast NeoplasmsDiagnostic ImagingFemaleHumansMammographyMastectomy, SegmentalMiddle AgedNeoplasm StagingRadiographyTreatment OutcomeTumor BurdenBreast cancerGuidanceLocalizationLumpectomy

Identifiers

PMID31754951
PMCPMC6997262

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.