ArticleEuropean journal of epidemiology2019
Predicted lean body mass, fat mass and risk of lung cancer: prospective US cohort study.
Article in European journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Body mass index (BMI) and risk of lung cancer: a systematic review and meta-analysis of studies using directly measured and genetically proxied measures of BMI.Cancer causes & control : CCC · 2026Pooled it
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer.Cancer science · 2026Article
- Beyond nodules: body composition as a biomarker for future lung cancer.European radiology · 2025Article
- Association between body-mass index change and lung cancer risk in Korea: nested case-control study.BMC cancer · 2025Observational
- Metabolome-Wide Mendelian Randomization Identifies Maleate as a Mediator of the Effect of Obesity on the Risk of Small Cell Lung Cancer.Food science & nutrition · 2025Article
- Associations of sarcopenia, sarcopenia components and sarcopenic obesity with cancer incidence: A prospective cohort study of 414,094 participants in UK Biobank.International journal of cancer · 2025Article
- Diet and Prevention of Cardiovascular Disease and Cancer: JACC: CardioOncology State-of-the-Art Review.JACC. CardioOncology · 2025Review
- Dietary intervention enhances fertility in obese male mice by regulating SLC2As.Journal of molecular histology · 2025Article
- Association between lean body mass and osteoarthritis: a cross-sectional study from the NHANES 2007-2018.Scientific reports · 2025Article
- The non-linear relationships between fat mass and lean body mass with arthritis.Lipids in health and disease · 2025Article
- Predicting 3-year all-cause mortality in rectal cancer patients based on body composition and machine learning.Frontiers in nutrition · 2025Article
- Association of cardiovascular health with COPD (NHANES 2007-2020): mediating potential of lean body mass.Frontiers in endocrinology · 2025Article
- A validated estimate of visceral adipose tissue volume in relation to cancer risk.Journal of the National Cancer Institute · 2024Article
- Allometric fat mass index and alanine aminotransferase attenuate the associations of platelet parameters with lung cancer risk.Scientific reports · 2024Article
- Association of Metabolic Syndrome With Risk of Lung Cancer: A Population-Based Prospective Cohort Study.Chest · 2024Article
- Predicted lean body mass trajectories, and cancer risk and cancer-specific and all-cause mortality: A prospective cohort study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Obesity and lung cancer-a narrative review.Journal of thoracic disease · 2023Review
- Artificial Neural Network Models for Accurate Predictions of Fat-Free and Fat Masses, Using Easy-to-Measure Anthropometric Parameters.Biomedicines · 2023Article
- Association of predicted fat mass and lean body mass with diabetes: a longitudinal cohort study in an Asian population.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
An inverse association between body mass index (BMI) and risk of lung cancer has been reported. However, the association of body composition such as fat mass (FM) and lean body mass (LBM) with risk of lung cancer has not been fully investigated. Using two large prospective cohort studies (Nurses' Health Study, 1986-2014; Health Professionals Follow-up Study, 1987-2012) in the United States, we included 100,985 participants who were followed for occurrence of lung cancer. Predicted FM and LBM derived from validated anthropometric prediction equations were categorized by sex-specific deciles. During an average 22.3-year follow-up, 2615 incident lung cancer cases were identified. BMI showed an inverse association with lung cancer risk. Participants in the 10th decile of predicted FM and LBM had a lower risk of lung cancer compared with those in the 1st decile, but when mutually adjusted for each other, predicted FM was not associated with lung cancer risk (adjusted hazard ratio [aHR] = 0.98, 95% confidence interval [CI] 0.72-1.35; P(trend) = 0.97) whereas predicted LBM had an inverse association (aHR = 0.73, 95% CI 0.53-1.00; P(trend) = 0.03), especially among participants who were current smokers or had smoked in the previous 10 years (aHR = 0.55, 95% CI 0.36-0.84; P(trend) = 0.008). In conclusion, BMI was inversely associated with lung cancer risk. Based on anthropometric prediction equations, low LBM rather than low FM accounted for the inverse association between BMI and lung cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.