Evidence map›Paper›PMID 31754924›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2020

Economic evaluation of meningococcal vaccines: considerations for the future.

Hannah Christensen, Hareth Al-Janabi, Pierre Levy, Maarten J Postma, David E Bloom, Paolo Landa, Oliver Damm, David M Salisbury, Javier Diez-Domingo, Adrian K Towse and 8 more

Open access · hybridAbstract read
In one paragraph

Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Preventing invasive meningococcal disease in early infancy.Human vaccines & immunotherapeutics · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Impact of a Global Pandemic on Health Technology Assessment.Applied health economics and health policy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 6 countries.

Hannah ChristensenPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK. Hannah.Christensen@bristol.ac.uk.
Hareth Al-JanabiHealth Economics Unit, University of Birmingham, Birmingham, B15 2TT, UK.
Pierre LevyUniversité Paris-Dauphine, PSL Research University, LEDa [LEGOS], 75775, Paris, France.
Maarten J PostmaDepartment of Pharmacy, University Medical Center/University of Groningen, 9712 CP, Groningen, The Netherlands.
David E BloomDepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Harvard University, Cambridge, MA, 02115, USA.
Paolo LandaInstitute of Health Research, Medical School, University of Exeter, Exeter, EX1 2LU, UK.
Oliver DammSchool of Public Health, Bielefeld University, 33615, Bielefeld, Germany.
David M SalisburyCentre on Global Health Security, Royal Institute of International Affairs, London, SW1Y 4LE, UK.
Javier Diez-DomingoFISABIO-Public Health, 46020, Valencia, Spain.
Adrian K TowseOffice of Health Economics, London, SW1E 6QT, UK.
Paula K LorgellyOffice of Health Economics, London, SW1E 6QT, UK.
Koonal K ShahOffice of Health Economics, London, SW1E 6QT, UK.
Karla Hernandez-VillafuerteOffice of Health Economics, London, SW1E 6QT, UK.
Vinny SmithMeningitis Research Foundation, Newminster House, 27-29 Baldwin Street, Bristol, BS1 1LT, UK. vinnys@meningitis.org.
Linda GlennieMeningitis Research Foundation, Newminster House, 27-29 Baldwin Street, Bristol, BS1 1LT, UK.
Claire WrightMeningitis Research Foundation, Newminster House, 27-29 Baldwin Street, Bristol, BS1 1LT, UK.
Laura YorkVaccine Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, 19426, USA.
Raymond FarkouhPfizer Inc, Collegeville, PA, 19426, USA.
Meningitis Research Foundation · GBOffice Of Health Economics · GBPfizer (United States) · USBielefeld University · DEChatham House · GBFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESHarvard University · USHeidelberg University · DEUniversité Paris Dauphine-PSL · FRUniversity of Birmingham · GBUniversity of Bristol · GBUniversity of Exeter · GBUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2018, a panel of health economics and meningococcal disease experts convened to review methodologies, frameworks, and decision-making processes for economic evaluations of vaccines, with a focus on evaluation of vaccines targeting invasive meningococcal disease (IMD). The panel discussed vaccine evaluation methods across countries; IMD prevention benefits that are well quantified using current methods, not well quantified, or missing in current cost-effectiveness methodologies; and development of recommendations for future evaluation methods. Consensus was reached on a number of points and further consideration was deemed necessary for some topics. Experts agreed that the unpredictability of IMD complicates an accurate evaluation of meningococcal vaccine benefits and that vaccine cost-effectiveness evaluations should encompass indirect benefits, both for meningococcal vaccines and vaccines in general. In addition, the panel agreed that transparency in the vaccine decision-making process is beneficial and should be implemented when possible. Further discussion is required to ascertain: how enhancing consistency of frameworks for evaluating outcomes of vaccine introduction can be improved; reviews of existing tools used to capture quality of life; how indirect costs are considered within models; and whether and how the weighting of quality-adjusted life-years (QALY), application of QALY adjustment factors, or use of altered cost-effectiveness thresholds should be used in the economic evaluation of vaccines.

Indexed as

Cost-Benefit AnalysisMeningococcal InfectionsMeningococcal VaccinesHumansModels, EconomicQuality of LifeVaccinationMeningococcal VaccinesCost-effectivenessMeningitisMeningococcalQALYVaccine

Identifiers

PMID31754924
PMCPMC7072054
OpenAlexW2991330128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.