ArticleAnnals of intensive care2019
Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS.
Article in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Advanced respiratory mechanics assessment in mechanically ventilated obese and non-obese patients with or without acute respiratory distress syndrome.Critical care (London, England) · 2023Trial
- Early change in ventilatory ratio during prone positioning and 28-day mortality in patients with ARDS: a retrospective cohort study with exploratory eICU assessment.BMC pulmonary medicine · 2026Article
- Influence of leaks and mask design on COBMJ open respiratory research · 2026Observational
- Reply to "PROVENT-C19 repeated prone positioning analysis": not everything that differs is inconsistent.Journal of anesthesia, analgesia and critical care · 2026Article
- Time-dependent effects in consecutive cycles of prone positioning for acute respiratory failure: insights from the PROVENT-C19 Registry.Journal of anesthesia, analgesia and critical care · 2026Article
- Beyond the PaOAnnals of intensive care · 2026Review
- Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study.BMC anesthesiology · 2025Article
- Mechanics Meet Perfusion: A Retrospective Cohort Study on Optimizing Ventilatory Parameters in Traumatic Flail Chest.Cureus · 2025Article
- EIT Outperforms Quantitative CT in Stratifying ARDS Severity After Lung Transplantation: A Retrospective Study.The clinical respiratory journal · 2025Article
- Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange.Critical care explorations · 2025Article
- Article
- Lung Ultrasound After COVID-19: A Pivotal Moment for Clinical Integration-Navigating Challenges and Seizing Opportunities.Healthcare (Basel, Switzerland) · 2025Review
- Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome.Intensive care medicine experimental · 2025Article
- Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients.Annals of intensive care · 2025Article
- Ventilatory variables and computed tomography features in COVID-19 ARDS and non-COVID-19-related ARDS: a prospective observational cohort study.European journal of medical research · 2025Observational
- Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome.Annals of intensive care · 2025Article
- Associations of mechanical power, ventilatory ratio, and other respiratory indices with mortality in patients with acute respiratory distress syndrome undergoing pressure-controlled mechanical ventilation.Frontiers in medicine · 2025Article
- Correlation of sonographic and radiographic scores of lung edema and metrics of shunt, dead space, and respiratory mechanics in invasively ventilated patients.Critical care science · 2025Observational
- Predictive value of invasive mechanical ventilation parameters for mortality in COVID-19 related ARDS: a retrospective cohort study.Scientific reports · 2024Observational
- Lung microbiota composition, respiratory mechanics, and outcomes in COVID-19-related ARDS.Microbiology spectrum · 2024Observational
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This study aimed to compare various methods for dead space estimation and the ventilatory ratio in patients with acute respiratory distress syndrome (ARDS) and to determine their independent values for predicting death at day 30. The present study is a post hoc analysis of a prospective observational cohort study of ICUs of two tertiary care hospitals in the Netherlands.
resultsIndividual patient data from 940 ARDS patients were analyzed. Estimated dead space fraction and the ventilatory ratio at days 1 and 2 were significantly higher among non-survivors (p < 0.01). Dead space fraction calculation using the estimate from physiological variables [V
conclusionsEstimated methods for dead space calculation and the ventilatory ratio during the early course of ARDS are associated with mortality at day 30 and add statistically significant but limited improvement in the predictive accuracy to indices of oxygenation and respiratory system mechanics at the second day of mechanical ventilation.
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