Evidence map›Paper›PMID 31754830›Full record

ArticlePflugers Archiv : European journal of physiology2020

The functional association between the sodium/bicarbonate cotransporter (NBC) and the soluble adenylyl cyclase (sAC) modulates cardiac contractility.

María S Espejo, Alejandro Orlowski, Alejandro M Ibañez, Romina A Di Mattía, Fernanda Carrizo Velásquez, Noelia S Rossetti, María C Ciancio, Verónica C De Giusti, Ernesto A Aiello

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. The role of soluble adenylyl cyclase in sensing and regulating intracellular pH.Pflugers Archiv : European journal of physiology · 2024
    Review
  2. Article
  3. Frontiers in cardiovascular medicine · 2022
    Article
  4. Article
  5. Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021
    Observational
  6. Differential effects of bicarbonate on severe hypoxia- and hypercapnia-induced cardiac malfunctions in diverse fish species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

María S EspejoCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
Alejandro OrlowskiCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
Alejandro M IbañezCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
Romina A Di MattíaCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
Fernanda Carrizo VelásquezCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
Noelia S RossettiCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
María C CiancioCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina.
Verónica C De GiustiCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina. degiustiveronica@gmail.com.
Ernesto A AielloCentro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, Calle 60 y 120, 1900, La Plata, Argentina. aaiello@ciclaplata.org.ar.ORCID 0000-0002-8914-5067
Consejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The soluble adenylyl cyclase (sAC) was identified in the heart as another source of cyclic AMP (cAMP). However, its cardiac physiological function is unknown. On the other hand, the cardiac Na

Indexed as

Myocardial ContractionAdenylyl Cyclase InhibitorsAdenylyl CyclasesAnimalsBenzamidesCalcium SignalingCells, CulturedCyclic AMP-Dependent Protein KinasesHeart VentriclesIsoquinolinesMaleMyocytes, CardiacRatsRats, WistarRyanodine Receptor Calcium Release ChannelSodium-Bicarbonate SymportersAdenylyl Cyclase InhibitorsAdenylyl CyclasesBenzamidesCyclic AMP-Dependent Protein KinasesIsoquinolinesN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideRyanodine Receptor Calcium Release ChannelS 0859 compoundSodium-Bicarbonate SymportersSulfonamidescAMPCardiac myocytesSodium/bicarbonate cotransporterSoluble adenylyl cyclase

Identifiers

PMID31754830
OpenAlexW2990412264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.