ArticleInternational journal of colorectal disease2020
Preoperative immunonutrition in frail patients with colorectal cancer: an intervention to improve postoperative outcomes.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The use of preoperative enteral immunonutrition in patients undergoing elective colorectal cancer surgery: A systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis.BMC cancer · 2024Pooled it
- EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults.Surgical endoscopy · 2024Guideline
- Effects of prehabilitation on postoperative outcomes in frail cancer patients undergoing elective surgery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Trial
- Construction and validation of frailty risk prediction model in elderly patients with colorectal cancer.BMC geriatrics · 2025Article
- Article
- Effect of perioperative ONS combined with intestinal microecology in patients with colorectal cancer: a randomized clinical trial.Frontiers in nutrition · 2025Article
- The Association Between Intraoperative Compromised Intestinal Integrity and Postoperative Complications in Cancer Patients.Annals of surgical oncology · 2024Article
- The influence of serum cholinesterase levels and sarcopenia on postoperative infectious complications in colorectal cancer surgery.Surgery today · 2023Article
- Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?Current oncology (Toronto, Ont.) · 2023Article
- Significance of osteopenia in elderly patients undergoing emergency gastrointestinal surgery.Annals of gastroenterological surgery · 2022Article
- Preoperative serum cholinesterase levels as a risk factor of postoperative complications for the elderly undergoing emergency surgery.Surgery today · 2021Article
- Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery: ERAS for Patients Undergoing Cytoreductive Surgery with or Without HIPEC.Annals of surgical oncology · 2021Article
- Application of NRS2002 in Preoperative Nutritional Screening for Patients with Liver Cancer.Journal of oncology · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to evaluate whether preoperative immunonutrition can shorten length of stay and improve postoperative outcomes in frail patients who are candidates for major oncologic colorectal surgery.
methodsA single center retrospective analysis of a prospectively collected database of frail patients, who underwent surgery with curative intent for colorectal cancer between January 2014 and December 2017, was performed. From March 2016, frail oncological patients undergoing major surgery were recommended to receive preoperative immunonutrition; their postoperative outcomes were compared to those of patients not treated with any preoperative nutritional support. Propensity score matching in a 1:1 ratio was used to balance patient characteristics.
resultsOverall, 175 patients were included in the study. Of 74 patients receiving immunonutrition, 65 were matched with the group not treated with immunonutrition (n = 101). Baseline characteristics were comparable after matching. Although differences in postoperative length of stay were nonsignificant (p = 0.38), patients who received immunonutrition showed a shorter gastrointestinal (GI) recovery time (3.00 [2.00-4.00] versus 4.00 [2.00-5.00], p = 0.04), a lower rate of situs site infections complications (0.31 [0.10, 0.94], p = 0.04) and less need of antibiotic treatment (0.19 [0.06, 0.64], p = 0.01).
conclusionPreoperative immunonutrition was found to reduce both postoperative situs site infections and need of antibiotic treatment during the postoperative course. This study encourages the use of preoperative immune-enhancing nutrition as a part of multimodal prehabilitation programs in the management of frail colorectal cancer patients.
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