Evidence map›Paper›PMID 31754793›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

[

Rohini Sharma, Pablo Oriol Valls, Marianna Inglese, Suraiya Dubash, Michelle Chen, Hani Gabra, Ana Montes, Amarnath Challapalli, Mubarik Arshad, George Tharakan and 5 more

Open access · hybridAbstract readClinical Trial, Phase I
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. RepurposingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Rohini SharmaDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK. r.sharma@imperial.ac.uk.
Pablo Oriol VallsDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Marianna IngleseDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Suraiya DubashDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Michelle ChenDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Hani GabraDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Ana MontesDepartment of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Amarnath ChallapalliBristol Cancer Institute, UH Bristol NHS Foundation Trust, Bristol, UK.
Mubarik ArshadDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
George TharakanDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Ed ChambersDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Tom ColeDepartment of Medicine, Division of Experimental Medicine, NIHR Imperial Clinical Research Facility, Imperial College London, London, UK.
Jingky P Lozano-KuehneDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Tara D BarwickDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Eric O AboagyeDepartment of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0HS, UK.
Imperial College London · GBGuy's and St Thomas' NHS Foundation Trust · GBSapienza University of Rome · ITUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

Medical Research Council MC_U120081322Medical Research Council MR/J007986/1Medical Research Council MR/N020782/1
6 · The paper itself

Abstract

backgroundAngiogenesis is a driver of platinum resistance in ovarian cancer. We assessed the effect of combination pazopanib and paclitaxel followed by maintenance pazopanib in patients with platinum-resistant/refractory ovarian cancer. Integrins α PATIENTS AND

methodsWe conducted an open-label, phase Ib study in patients with platinum-resistant/refractory ovarian cancer. Patients received 1 week of single-agent pazopanib (800 mg daily) followed by combination therapy with weekly paclitaxel (80 mg/m

resultsFourteen patients were included in the intention-to-treat analysis. Complete and partial responses were seen in seven patients (54%). Median progression-free survival (PFS) was 10.63 months, and overall survival (OS) was 18.5 months. Baseline [

conclusionsCombination therapy followed by maintenance pazopanib is effective and tolerable in platinum-resistant/refractory ovarian cancer. [

Indexed as

Ovarian NeoplasmsPaclitaxelAntineoplastic Combined Chemotherapy ProtocolsBiomarkersDrug Resistance, NeoplasmFemaleHumansIndazolesPeptidesPolyethylene GlycolsPositron-Emission TomographyPyrimidinesSulfonamidesAH 111585BiomarkersIndazolesPaclitaxelpazopanibPeptidesPolyethylene GlycolsPyrimidinesSulfonamides[18F]FluciclatideAngiogenesisOvarian cancerPazopanibPET imagingPlatinum resistance

Identifiers

PMID31754793
PMCPMC7101300
OpenAlexW2990848529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.