Evidence map›Paper›PMID 31754754›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.

L Malmgren, F E McGuigan, A Christensson, K E Akesson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

L MalmgrenDepartment of Clinical Sciences Malmö, Lund University, 214 28, Malmö, Sweden.ORCID https://orcid.org/0000-0003-3296-7083
F E McGuiganDepartment of Clinical Sciences Malmö, Lund University, 214 28, Malmö, Sweden.ORCID https://orcid.org/0000-0002-8033-9981
A ChristenssonDepartment of Clinical Sciences Malmö, Lund University, 214 28, Malmö, Sweden.ORCID https://orcid.org/0000-0002-7328-8418
K E AkessonDepartment of Clinical Sciences Malmö, Lund University, 214 28, Malmö, Sweden. kristina.akesson@med.lu.se.ORCID https://orcid.org/0000-0003-3024-2804
Malmö University · SE

Funding

Forskningsrådet om Hälsa, Arbetsliv och Välfärd Grant 2007-2125Vetenskapsrådet K2015-52X-14691-13-4
6 · The paper itself

Abstract

Reduced kidney function is associated with an increased fracture risk, although the relationship between an age-related decline and fractures needs further investigation. We followed kidney function and fracture risk for 10 years. A mild-moderate decline in kidney function was associated with fracture, but not in advanced age.

introductionWith age, kidney function declines. Though well known that chronic kidney disease is associated with increased fracture risk, the extent to which the typical age-related decline contributes is unclear. In the OPRA cohort, a longitudinal study of older non-selected women, we investigated the association between kidney function and fracture.

methodsCystatin C-based kidney function estimates were available at age 75 (n = 981) and 80 (n = 685). Women were categorized by kidney function: normal (CKD stages 1 and 2), mild-moderate (3a), poor (3b-5), and imminent, short- and long-term fracture risk investigated. BMD measurements and kidney function for risk prediction were also evaluated; women were categorized by both reduced kidney function (stages 3-5) and osteoporosis status.

resultsIn the short term, 2-3 years, mild-moderate kidney dysfunction was associated with the highest risk increase: osteoporotic fractures (2 years HR

conclusionOlder women with mild-moderate reduction of kidney function are at increased risk of fractures, but not those with the worst function. Our findings furthermore confirm the value of osteoporosis assessment and it is possible that in this age group, age-related decline of kidney function has limited contribution compared with BMD.

Indexed as

Bone DensityFractures, BoneKidneyOsteoporosisAgedAged, 80 and overFemaleGlomerular Filtration RateHumansLongitudinal StudiesRisk FactorsAgingBone mineral densityChronic kidney diseaseEstimated glomerular filtration rateFractureWomen

Identifiers

PMID31754754
PMCPMC6946753
OpenAlexW2990603474

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.