Evidence map›Paper›PMID 31754752›Full record

SynthesisInternational orthopaedics2020

Is there scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections? A systematic review.

Ana Isabel Moreira, Luzia Mendes, José António Pereira

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International orthopaedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  9. Case reports in infectious diseases · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ana Isabel MoreiraFaculty of Dental Medicine of University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal. up201405245@fmd.up.pt.ORCID 0000-0002-3614-8299
Luzia MendesFaculty of Dental Medicine of University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.ORCID 0000-0003-2324-5847
José António PereiraFaculty of Dental Medicine of University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.ORCID 0000-0002-7737-2166
Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo re-assess the scientific literature to ascertain if there is scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections.

introductionProsthetic joint infections occur in approximately 0.3-2% of patients and, of these, around 6-13% are thought to be caused by oral bacteria. Antibiotic prophylaxis prior to dental procedures as a means to prevent a prosthetic joint infection has been controversial throughout the years. However, it remains unclear to what extent it has a beneficial effect. We do know that bacteraemia of oral origin is directly proportional to any ongoing inflammation or infection, and that a diseased periodontium may act as an entry for bacteria to spread to distant locations, through the bloodstream, and potentially be the cause of distant site infections. MATERIALS AND

methodsUpdated literature search using the PubMed (Medline), and the Clarivate Analytics databases, to identify eligible articles since the previous searches up to April 2019 (last 5 years).

resultsNo studies that relate periodontal disease to the development of a prosthetic joint infection were found.

conclusionCurrently, there is no evidence to support or exclude the need of antibiotic prophylaxis as a means to decrease the risk of prosthetic joint infections in patients with periodontal disease.

Indexed as

Antibiotic ProphylaxisAnti-Bacterial AgentsArthroplasty, ReplacementHumansJoint DiseasesPeriodontal DiseasesProsthesis-Related InfectionsRisk FactorsAnti-Bacterial AgentsAntibiotic prophylaxisOral microbiotaPeriodontal diseasePeriodontal pathogensPeriodontitisPJIProsthetic joint infection

Identifiers

PMID31754752
OpenAlexW2990736636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.