Evidence map›Paper›PMID 31754736›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2020

Immunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation.

Priscilla A T Pereira, Claudia S Bitencourt, Mouzarllem B Reis, Fabiani G Frantz, Carlos A Sorgi, Camila O S Souza, Célio L Silva, Luiz G Gardinassi, Lúcia H Faccioli

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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Priscilla A T Pereira *Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
Claudia S Bitencourt *Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
Mouzarllem B ReisDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
Fabiani G FrantzDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
Carlos A SorgiDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
Camila O S SouzaDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil.
Célio L SilvaDepartamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Luiz G GardinassiDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil. gustavogardinassi@usp.br.
Lúcia H FaccioliDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida Do Café, s/n, Ribeirão Preto, SP, 14040-903, Brazil. faccioli@fcfrp.usp.br.
Universidade de São Paulo · BRCentro Universitário das Faculdades Metropolitanas Unidas · BRFundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302514/2015-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 150991/2011-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 1746212Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88882.317663/2019-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.363659/2019-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2007/04741-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2009/07169-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/07125-6Fundação de Amparo à Pesquisa do Estado de São Paulo EMU 2015/00658-1
6 · The paper itself

Abstract

OBJECTIVE AND

designInvestigate survival outcomes, and immunological and metabolomic effects of hyaluronidase (Hz) treatment during mouse models of acute inflammation and sepsis.

methodsSurvival of C57Bl/6 mice was monitored after lethal challenge with lipopolysaccharide (LPS) or cecal and ligation puncture (CLP)-induced sepsis and treated with Hz or saline. Mice were also challenged with LPS and treated with Hz for leukocyte counting, cytokine quantification and determination of metabolomic profiles in the peritoneal fluid.

resultsHz treatment improved survival outcomes after lethal challenge with LPS or CLP-induced sepsis. LPS challenge promoted acute neutrophil accumulation and production of interleukin-1β (IL-1β) and IL-6 in the peritoneum, whereas Hz treatment suppressed neutrophil infiltration and cytokine production. We further characterized the metabolomic alterations caused by LPS challenge, which predicted activity of metabolic pathways related to fatty acids and eicosanoids. Hz treatment had a profound effect over the metabolic response, reflected by reductions of the relative levels of fatty acids.

conclusionCollectively, these data demonstrate that Hz treatment is associated with metabolic reprogramming of pathways that sustain the inflammatory response.

Indexed as

Acute DiseaseAnimalsAscitic FluidDisease Models, AnimalEicosanoidsFatty AcidsHyaluronoglucosaminidaseImmunomodulationInterleukin-1betaInterleukin-6Leukocyte CountLipopolysaccharidesMaleMetabolic Networks and PathwaysMetabolomicsMice, Inbred C57BLEicosanoidsFatty AcidsHyaluronoglucosaminidaseIL1B protein, mouseInterleukin-1betaInterleukin-6interleukin-6, mouseLipopolysaccharidesAcute inflammationHyaluronic acidHyaluronidaseMetabolomicsSepsis

Identifiers

PMID31754736
OpenAlexW2990030095

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.