ArticleThe Journal of infectious diseases2020
Infectious Etiologies of Intussusception Among Children <2 Years Old in 4 Asian Countries.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06365333 (Pneumatic Reduction For Intussusception In Children), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study In An Ultrahigh Volume Center
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Management of intussusception in children: A systematic review.Journal of pediatric surgery · 2021Pooled it
- [Epidemiological characteristics of intussusception in children aged 0-3 years in Jiangsu Province from 2018 to 2023].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Determinants of ultrasound-guided reduction failure and pathological lead points in pediatric intussusception.Pediatric surgery international · 2026Article
- A nationwide comparative study of pediatric and adult intussusception in emergency departments during the COVID-19.Scientific reports · 2025Article
- Jejunojejunal Intussusception in an 11 year old: A Case Report.JNMA; journal of the Nepal Medical Association · 2025Article
- Article
- Article
- Recurrent Intussusception in a Pediatric Patient: The Role of the Mesoappendix as a Potential Culprit.Cureus · 2024Article
- Infectious etiology of intussusception in Indian children less than 2 years old: a matched case-control analysis.Gut pathogens · 2024Article
- Review
- Microorganisms Detected in Intussusception Cases and Controls in Children <3 Years in South Africa From 2013 to 2017.Open forum infectious diseases · 2023Article
- Intussusception and COVID-19 in Children: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2022Review
- Pediatric case of colonic perivascular epithelioid cell tumor complicated with intussusception and anal incarceration: A case report.World journal of gastrointestinal oncology · 2022Article
- Ileocolic intussusception in pediatric SARS-CoV-2 patients: experience at a tertiary pediatric center.Pediatric surgery international · 2022Article
- Article
- Changes in the Incidence of Intussusception and Infectious Diseases After the COVID-19 Pandemic in Korea.Journal of Korean medical science · 2022Article
- Review of Over 15 Years Postmarketing Safety Surveillance Spontaneous Data for the Human Rotavirus Vaccine (Rotarix) on Intussusception.Drug safety · 2022Article
- Article
- Intussusception in an Infant With SARS-CoV-2 Infection: A Case Report and a Review of the Literature.Frontiers in pediatrics · 2021Article
- Point-of-Care Ultrasound May Reduce Misdiagnosis of Pediatric Intussusception.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 12 institutions in 5 countries.
Funding
Abstract
backgroundThe etiology of intussusception, the leading cause of bowel obstruction in infants, is unknown in most cases. Adenovirus has been associated with intussusception and slightly increased risk of intussusception with rotavirus vaccination has been found. We conducted a case-control study among children <2 years old in Bangladesh, Nepal, Pakistan, and Vietnam to evaluate infectious etiologies of intussusception before rotavirus vaccine introduction.
methodsFrom 2015 to 2017, we enrolled 1-to-1 matched intussusception cases and hospital controls; 249 pairs were included. Stool specimens were tested for 37 infectious agents using TaqMan Array technology. We used conditional logistic regression to estimate odds ratio (OR) and 95% confidence interval (CI) of each pathogen associated with intussusception in a pooled analysis and quantitative subanalyses.
resultsAdenovirus (OR, 2.67; 95% CI, 1.75-4.36) and human herpes virus 6 (OR, 3.50; 95% CI, 1.15-10.63) were detected more frequently in cases than controls. Adenovirus C detection <20 quantification cycles was associated with intussusception (OR, 18.59; 95% CI, 2.45-140.89). Wild-type rotavirus was not associated with intussusception (OR, 1.07; 95% CI, 0.52-2.22).
conclusionsIn this comprehensive evaluation, adenovirus and HHV-6 were associated with intussusception. Future research is needed to better understand mechanisms leading to intussusception, particularly after rotavirus vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.