Evidence map›Paper›PMID 31754646›Full record

ArticleCommunications biology2019

The podocin V260E mutation predicts steroid resistant nephrotic syndrome in black South African children with focal segmental glomerulosclerosis.

Melanie A Govender, June Fabian, Errol Gottlich, Cecil Levy, Glenda Moonsamy, Heather Maher, Cheryl A Winkler, Michèle Ramsay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Melanie A Govender1Sydney Brenner Institute for Molecular Bioscience and Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
June Fabian2Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa.
Errol Gottlich2Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa.
Cecil Levy5Nelson Mandela Children's Hospital, Division of Nephrology, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Glenda Moonsamy6Charlotte Maxeke Johannesburg Academic Hospital, Division of Nephrology, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Heather Maher2Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa.
Cheryl A Winkler7Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD USA.ORCID 0000-0001-5552-0917
Michèle Ramsay1Sydney Brenner Institute for Molecular Bioscience and Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-4156-4801
University of the Witwatersrand · ZANational Health Laboratory Service · ZALeidos (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In black African children with focal segmental glomerulosclerosis (FSGS) there are high rates of steroid resistance. The aim was to determine genetic associations with apolipoprotein L1 (

Indexed as

AllelesAmino Acid SubstitutionMutationApolipoprotein L1Black PeopleChildChild, PreschoolDrug ResistanceFemaleGenotypeGlomerulosclerosis, Focal SegmentalHaplotypesHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsAPOL1 protein, humanApolipoprotein L1Intracellular Signaling Peptides and ProteinsMembrane ProteinsNPHS2 proteinSteroidsGeneticsMolecular medicine

Identifiers

PMID31754646
PMCPMC6858321
OpenAlexW2985386436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.