Evidence map›Paper›PMID 31754645›Full record

ArticleCommunications biology2019

Delta oscillations phase limit neural activity during sevoflurane anesthesia.

Shubham Chamadia, Juan C Pedemonte, Eunice Y Hahm, Jennifer Mekonnen, Reine Ibala, Jacob Gitlin, Breanna R Ethridge, Jason Qu, Rafael Vazquez, James Rhee and 3 more

Abstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Trial
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  15. Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Ketamine induces EEG oscillations that may aid anesthetic state but not dissociation monitoring.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shubham Chamadia1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Juan C Pedemonte1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Eunice Y Hahm1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Jennifer Mekonnen1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Reine Ibala1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Jacob Gitlin1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Breanna R Ethridge1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Jason Qu1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Rafael Vazquez1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
James Rhee1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Erika T Liao3Tulane University of Medicine, New Orleans, LA 70112 USA.
Emery N Brown1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.
Oluwaseun Akeju1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA.ORCID 0000-0002-6740-1250

Funding

Project 4: Mathematical Modeling Studies of Anesthetic ActionP01GM118269 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI KOPELL, NANCY · 2017 to 2021
$9.0M
NIGMS NIH HHS P01 GM118269
6 · The paper itself

Abstract

Understanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscillations have been postulated as a mechanism of sevoflurane general anesthesia. This postulate remains unproven. Therefore, we performed a single-site, randomized, cross-over, high-density electroencephalogram study of sevoflurane and sevoflurane-

Indexed as

Anesthesia, GeneralAnesthetics, InhalationElectroencephalographyElectrophysiological PhenomenaHumansNeuronsSevofluraneSynaptic TransmissionAnesthetics, InhalationSevofluraneNeural circuitsNeurophysiology

Identifiers

PMID31754645
PMCPMC6858348

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.