Evidence map›Paper›PMID 31754636›Full record

SynthesisWellcome open research2019

Treatment optimisation for hepatitis C in the era of combination direct-acting antiviral therapy: a systematic review and meta-analysis.

Christopher R Jones, Barnaby F Flower, Ella Barber, Bryony Simmons, Graham S Cooke

Abstract readSystematic Review
In one paragraph

Synthesis in Wellcome open research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Management of hepatitis C infections among Rohingya refugees, Bangladesh.Bulletin of the World Health Organization · 2026
    Article
  6. Targeting the SARS-CoV-2 reservoir in long COVID.The Lancet. Infectious diseases · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. CDC Recommendations for Hepatitis C Screening Among Adults - United States, 2020.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher R JonesDepartment of Infectious Disease, Imperial College London, London, W2 1NY, UK.ORCID https://orcid.org/0000-0002-6301-2282
Barnaby F FlowerDepartment of Infectious Disease, Imperial College London, London, W2 1NY, UK.ORCID https://orcid.org/0000-0002-2659-544X
Ella BarberDepartment of Infectious Disease, Imperial College London, London, W2 1NY, UK.
Bryony SimmonsDepartment of Infectious Disease, Imperial College London, London, W2 1NY, UK.ORCID https://orcid.org/0000-0002-3207-9935
Graham S CookeDepartment of Infectious Disease, Imperial College London, London, W2 1NY, UK.

Funding

Department of Health EME/14/02/17Department of Health RP-2016-07-012Medical Research Council MR/P025064/1Wellcome Trust 206296/Z/17/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

direct acting antiviralshepatitis C viruspersonalised medicinestratified medicinesustained virologic responsesystematic reviewtreatment optimisation

Identifiers

PMID31754636
PMCPMC6854875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.