Evidence map›Paper›PMID 31754628›Full record

ArticleNPJ breast cancer2019

Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density.

Maeve Mullooly, Babak Ehteshami Bejnordi, Ruth M Pfeiffer, Shaoqi Fan, Maya Palakal, Manila Hada, Pamela M Vacek, Donald L Weaver, John A Shepherd, Bo Fan and 13 more

Abstract read
In one paragraph

Article in NPJ breast cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Maeve Mullooly *1Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Babak Ehteshami Bejnordi *3Department of Pathology, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Ruth M Pfeiffer2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USA.
Shaoqi Fan2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USA.ORCID 0000-0001-5894-7510
Maya Palakal2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USA.
Manila Hada2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USA.
Pamela M Vacek5University of Vermont and University of Vermont Cancer Center, Burlington, VT USA.
Donald L Weaver5University of Vermont and University of Vermont Cancer Center, Burlington, VT USA.
John A Shepherd6University of California, San Francisco, San Francisco, CA USA.
Bo Fan6University of California, San Francisco, San Francisco, CA USA.
Amir Pasha Mahmoudzadeh6University of California, San Francisco, San Francisco, CA USA.
Jeff Wang8Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Serghei Malkov6University of California, San Francisco, San Francisco, CA USA.
Jason M Johnson9The University of Texas MD Anderson Cancer Center, Houston, TX USA.
Sally D Herschorn5University of Vermont and University of Vermont Cancer Center, Burlington, VT USA.ORCID 0000-0002-9193-6490
Brian L Sprague5University of Vermont and University of Vermont Cancer Center, Burlington, VT USA.
Stephen Hewitt10Center for Cancer Research, National Cancer Institute, Bethesda, MD USA.
Louise A Brinton2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USA.
Nico Karssemeijer3Department of Pathology, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Jeroen van der Laak3Department of Pathology, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.ORCID 0000-0001-7982-0754
Andrew Beck *4Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA.
Mark E Sherman *11Mayo Clinic, Jacksonville, FL USA.
Gretchen L Gierach *2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD USA.ORCID 0000-0002-0165-5522

Funding

Vermont Breast Cancer Molecular Characterization LaboratoryU01CA196383 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPRAGUE, BRIAN L, STEIN, JANET L · 2015 to 2020
$5.4M
NCI NIH HHS U01 CA196383
6 · The paper itself

Abstract

Breast density, a breast cancer risk factor, is a radiologic feature that reflects fibroglandular tissue content relative to breast area or volume. Its histology is incompletely characterized. Here we use deep learning approaches to identify histologic correlates in radiologically-guided biopsies that may underlie breast density and distinguish cancer among women with elevated and low density. We evaluated hematoxylin and eosin (H&E)-stained digitized images from image-guided breast biopsies (

Indexed as

Cancer epidemiologyCancer prevention

Identifiers

PMID31754628
PMCPMC6864056

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.