ReviewEFORT open reviews2019
Culture-negative periprosthetic joint infections.
Review in EFORT open reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Value of Next-Generation Sequencing in Periprosthetic Joint Infection: A Systematic Review.Orthopaedic surgery · 2022Pooled it
- Diagnostic Value of Synovial Fluid Biomarkers for Periprosthetic Joint Infection: A Prospective, Double-blind Trial.Medical science monitor : international medical journal of experimental and clinical research · 2023Trial
- The Clinical Impact of Metagenomic Next-Generation Sequencing for the Diagnosis of Periprosthetic Joint Infection.Infection and drug resistance · 2023Trial
- A novel diagnostic technology rapidly detects the presence of infection and defines antimicrobial sensitivities in organisms typical for joint infection.Bone & joint research · 2026Article
- Microbiological Patterns in Periprosthetic Knee Infections over a Decade: Analysis of Resistance Patterns, Temporal Trends, and Patient Residence.Antibiotics (Basel, Switzerland) · 2026Article
- Six-Week Protocol for Two-Stage Exchange Arthroplasty in a High-Risk Population.Arthroplasty today · 2026Article
- Article
- The Application of artificial intelligence in periprosthetic joint infection.Journal of advanced research · 2026Review
- Clinical application of synovial fluid albumin-to-globulin ratio as a novel biomarker in diagnosing chronic periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
- Advancing diagnostics in suspected periprosthetic joint infections using synthetic synovial fluid and microcalorimetry.Journal of bone and joint infection · 2026Article
- Integrated Single-Cell and Bulk RNA Sequencing Reveals the Diagnostic Value of Synovial Tissue Calprotectin and the MDSC-Associated Immune Microenvironment in Periprosthetic Joint Infection.Infection and drug resistance · 2026Article
- The serum C1q-to-CRP ratio performs well for diagnosing periprosthetic joint infection in revision arthroplasty.Frontiers in cellular and infection microbiology · 2026Article
- Beyond Cultures: The Evolving Role of Molecular Diagnostics, Synovial Biomarkers and Artificial Intelligence in the Diagnosis of Prosthetic Joint Infections.Journal of clinical medicine · 2025Review
- The Ongoing Struggle to Find a Gold Standard for PJI Diagnosis.Reports (MDPI) · 2025Review
- Article
- Outcomes of Long-Term Antibiotic Therapy for Prosthetic Joint Infection: A Cohort Study in a Canadian High-Volume Arthroplasty Center.Arthroplasty today · 2025Article
- Agreement Analysis Among Hip and Knee Periprosthetic Joint Infections Classifications.Diagnostics (Basel, Switzerland) · 2025Article
- Suction-Powered Intramedullary Bone Debridement Technology Compared to Conventional Curettage in Infected Revision Total Knee Arthroplasty.Arthroplasty today · 2025Article
- Preoperative Diagnosis of Periprosthetic Infection in Patients Undergoing Hip or Knee Revision Arthroplasties: Development and Validation of Machine Learning Algorithm.Diagnostics (Basel, Switzerland) · 2025Article
- Diagnosing Mycobacterium Kansasii in Shoulder Periprosthetic Joint Infection: A Rare Case Report.Journal of orthopaedic case reports · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Culture-negative periprosthetic joint infections (CN-PJI) pose a significant challenge in terms of diagnosis and management. The reported incidence of CN-PJI is reported to be between 7% and 15%.Fungi and mycobacterium are thought to be responsible for over 85% of such cases with more fastidious bacteria accounting for the rest.With the advent of polymerase chain reaction, mass spectrometry and next generation sequencing, identifying the causative organism(s) may become easier but such techniques are not readily available and are very costly.There are a number of more straightforward and relatively low-cost methods to help surgeons maximize the chances of diagnosing a PJI and identify the organisms responsible.This review article summarizes the main diagnostic tests currently available as well as providing a simple diagnostic clinical algorithm for CN-PJI. Cite this article:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.