ArticleNPJ systems biology and applications2019
A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications.
Article in NPJ systems biology and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Evaluating Genetic Regulators of MicroRNAs Using Machine Learning Models.International journal of molecular sciences · 2025Article
- Phenome-wide comorbidity network analysis reveals clinical risk patterns in enthesopathy and enthesitis.medRxiv : the preprint server for health sciences · 2025Article
- Protein swarm-based cause-effect analysis: effects of microRNAs on cooperation networks linking COVID-19 infections, atherosclerosis, and Alzheimer's disease.Frontiers in cardiovascular medicine · 2025Article
- Integrative analysis of miRNA expression data reveals a minimal signature for tumour cells classification.Computational and structural biotechnology journal · 2025Article
- Molecular Morbidity Score-Can MicroRNAs Assess the Burden of Disease?International journal of molecular sciences · 2024Review
- Uncovering genetic associations in the human diseasome using an endophenotype-augmented disease network.Bioinformatics (Oxford, England) · 2024Article
- Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model.World journal of gastroenterology · 2024Article
- Optimized network based natural language processing approach to reveal disease comorbidities in COVID-19.Scientific reports · 2024Article
- Predicting candidate biomarkers for COVID-19 associated with leukemia in children.American journal of clinical and experimental immunology · 2024Article
- DapBCH: a disease association prediction model Based on Cross-species and Heterogeneous graph embedding.Frontiers in genetics · 2023Article
- Exploring novel disease-disease associations based on multi-view fusion network.Computational and structural biotechnology journal · 2023Article
- Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure.Molecular medicine (Cambridge, Mass.) · 2022Article
- Review
- Human microRNA similarity in breast cancer.Bioscience reports · 2021Article
- Identifying miRNAs in multiple sclerosis gray matter lesions that correlate with atrophy measures.Annals of clinical and translational neurology · 2021Article
- Identification of the miRNA signature associated with survival in patients with ovarian cancer.Aging · 2021Article
- RNA-Associated Co-expression Network Identifies Novel Biomarkers for Digestive System Cancer.Frontiers in genetics · 2021Article
- Application of Multilayer Network Models in Bioinformatics.Frontiers in genetics · 2021Review
- Honeysuckle (Frontiers in pharmacology · 2021Article
- Identify DNA-Binding Proteins Through the Extreme Gradient Boosting Algorithm.Frontiers in genetics · 2021Review
Corrections and comments
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7 authors.
Funding
Abstract
Disease-disease relationships (e.g., disease comorbidities) play crucial roles in pathobiological manifestations of diseases and personalized approaches to managing those conditions. In this study, we develop a network-based methodology, termed meta-path-based Disease Network (mpDisNet) capturing algorithm, to infer disease-disease relationships by assembling four biological networks: disease-miRNA, miRNA-gene, disease-gene, and the human protein-protein interactome. mpDisNet is a meta-path-based random walk to reconstruct the heterogeneous neighbors of a given node. mpDisNet uses a heterogeneous skip-gram model to solve the network representation of the nodes. We find that mpDisNet reveals high performance in inferring clinically reported disease-disease relationships, outperforming that of traditional gene/miRNA-overlap approaches. In addition, mpDisNet identifies network-based comorbidities for pulmonary diseases driven by underlying miRNA-mediated pathobiological pathways (i.e., hsa-let-7a- or hsa-let-7b-mediated airway epithelial apoptosis and pro-inflammatory cytokine pathways) as derived from the human interactome network analysis. The mpDisNet offers a powerful tool for network-based identification of disease-disease relationships with miRNA-mediated pathobiological pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.