ArticleFungal biology and biotechnology2019
Dissecting cellobiose metabolic pathway and its application in biorefinery through consolidated bioprocessing in
Article in Fungal biology and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Unlocking raw-corncob consolidated bioprocessing for malic acid production by DyP-enabled lignin deconstruction inSynthetic and systems biotechnology · 2027Article
- Engineering Thermothelomyces heterothallica for cellobionate production.Bioresources and bioprocessing · 2026Article
- Engineering thiamine pyrophosphate metabolism improves consolidated bioprocessing for cellulosic ethanol with inorganic nitrogen in Myceliophthora thermophila.Biotechnology for biofuels and bioproducts · 2026Article
- Transcription factor MtCLR-2 regulates cellulase production via direct modulation of Mtegl2 and Mtbgl1 expression in Myceliophthora thermophila.Microbial cell factories · 2026Article
- Redox engineering of thermophilic fungusMycology · 2026Article
- Selection of reference genes in Thermothelomyces fergusii: insights from genomic and expression analysis in response to different carbon sources.BMC genomics · 2025Article
- Bacterial community function increases leaf growth in a pitcher plant experimental system.mSystems · 2024Article
- Construction of an enzyme-constrained metabolic network model for Myceliophthora thermophila using machine learning-based kMicrobial cell factories · 2024Article
- Independent metabolism of oligosaccharides is the keystone of synchronous utilization of cellulose and hemicellulose inPNAS nexus · 2024Article
- Rewiring metabolic flux to simultaneously improve malate production and eliminate by-product succinate accumulation by Myceliophthora thermophila.Microbial biotechnology · 2024Article
- Unveiling a classical mutant in the context of the GH3 β-glucosidase family in Neurospora crassa.AMB Express · 2024Article
- The transcriptional factor Clr-5 is involved in cellulose degradation through regulation of amino acid metabolism in Neurospora crassa.BMC biotechnology · 2023Article
- Development of an efficient protein expression system in the thermophilic fungus Myceliophthora thermophila.Microbial cell factories · 2023Article
- Coordination of consolidated bioprocessing technology and carbon dioxide fixation to produce malic acid directly from plant biomass in Myceliophthora thermophila.Biotechnology for biofuels · 2021Article
- Metabolic engineering of the cellulolytic thermophilic fungusBiotechnology for biofuels · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLignocellulosic biomass has long been recognized as a potential sustainable source for industrial applications. The costs associated with conversion of plant biomass to fermentable sugar represent a significant barrier to the production of cost-competitive biochemicals. Consolidated bioprocessing (CBP) is considered a potential breakthrough for achieving cost-efficient production of biomass-based fuels and commodity chemicals. During the degradation of cellulose, cellobiose (major end-product of cellulase activity) is catabolized by hydrolytic and phosphorolytic pathways in cellulolytic organisms. However, the details of the two intracellular cellobiose metabolism pathways in cellulolytic fungi remain to be uncovered.
resultsUsing the engineered malic acid production fungal strain JG207, we demonstrated that the hydrolytic pathway by β-glucosidase and the phosphorolytic pathway by phosphorylase are both used for intracellular cellobiose metabolism in
conclusionsThis is the first report of detailed investigation of intracellular cellobiose catabolism in cellulolytic fungus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.