ArticleFrontiers in zoology2019
Characterizing the composition, metabolism and physiological functions of the fatty liver in
Article in Frontiers in zoology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
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- Label-free photoacoustic imaging of glassfrog development.Photoacoustics · 2025Article
- Developmental Patterns of Hepatic Peroxisome Proliferator-Activated Receptor (PPAR) Expression in Xenopus laevis and Response to Pharmaceutical Agonists During Metamorphic Climax.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- The gut-liver axis plays a limited role in mediating the liver's heat susceptibility of Chinese giant salamander.BMC genomics · 2025Article
- Feasibility Evaluation of Dried Whole Egg Powder Application in Tadpole (Animals : an open access journal from MDPI · 2025Article
- Every Gain Comes With Loss: Ecological and Physiological Shifts Associated With Polyploidization in a Pygmy Frog.Molecular biology and evolution · 2025Article
- Article
- Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum.NPJ Regenerative medicine · 2024Article
- Phenotypic and Transcriptomic Analysis Revealed a Lack of Risk Perception by Native Tadpoles Toward Novel Non-Native Fish.Ecology and evolution · 2024Article
- What frog gill resorption brings: loss of function, cell death, and metabolic reorganization.Frontiers in zoology · 2024Article
- Gut microbiota reflect adaptation of cave-dwelling tadpoles to resource scarcity.The ISME journal · 2024Article
- Integrative proteome and metabolome analyses reveal molecular basis of the tail resorption during the metamorphic climax ofFrontiers in cell and developmental biology · 2024Article
- Salidroside ameliorates memory impairment following long-term ethanol intake in rats by modulating the altered intestinal microbiota content and hippocampal gene expression.Frontiers in microbiology · 2023Article
- Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation.Chinese medicine · 2022Article
- Local problems need global solutions: The metabolic needs of regenerating organisms.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Review
- Multi-Omics Approaches Revealed the Associations of Host Metabolism and Gut Microbiome With Phylogeny and Environmental Adaptation in Mountain Dragons.Frontiers in microbiology · 2022Article
- Review
- Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax.Frontiers in zoology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFat storage is required for the life cycle of many organisms. The primary fat depot for most vertebrates is white adipose tissue. However, in primitive vertebrates (e.g., agnathan group and elasmobranchs), the liver is usually responsible for fat storage. Among the vertebrates, amphibians have a unique status, as their larvae live in the water and exhibit some primitive traits that are similar to fish. Although it has been recognized that adult frogs use their abdominal white adipose tissue as a primary fat depot, how tadpoles store their fat is still inconclusive. The metabolic traits and physiological functions of primitive fat depots may have wide-ranging implications on the pathology of abnormal lipid deposition in mammals and the evolution of fat storage.
results
conclusionTo the best of our knowledge, this is the first report that liver can be the primary fat depot in vertebrates with higher evolutionary status than bony fish. The unique hepatic histological and metabolic traits likely either guard their liver against lipotoxicity or make their hepatocytes adapt to fat accumulation. This fatty liver could be a primitive counterpart of mammalian white adipose tissue (WAT). In addition, our study showed that the hepatic reserves of tadpoles, especially TG content, may provide body condition signals to modulate metamorphosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.