Evidence map›Paper›PMID 31754335›Full record

ArticleInternational journal of biological sciences2019

Downregulation of miR-199a-3p mediated by the CtBP2-HDAC1-FOXP3 transcriptional complex contributes to acute lung injury by targeting

Zhi Chen, Wei-Hua Dong, Qiang Chen, Qiu-Gen Li, Zhong-Min Qiu

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  16. Epigenetic Mechanisms of Inflammasome Regulation.International journal of molecular sciences · 2020
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zhi ChenDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Wei-Hua DongDepartment of Critical Care Medicine, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, Jiangxi, China.
Qiang ChenDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Qiu-Gen LiDepartment of Pulmonary and Critical Care Medicine, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, Jiangxi, China.
Zhong-Min QiuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Tongji Hospital · CNJiangxi Provincial People's Hospital · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence indicates that microRNAs (miRNAs) play fundamental roles in the pathogenesis of multiple diseases, including acute lung injury (ALI). Here, we discovered that miR-199a-3p was significantly downregulated in ALI lung tissues using a microarray analysis.

Indexed as

A549 CellsAcute Lung InjuryAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCytokinesForkhead Transcription FactorsGene Expression RegulationHumansLipopolysaccharidesMicroRNAsNLR ProteinsPromoter Regions, GeneticProtein BindingU937 CellsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCytokinesForkhead Transcription FactorsFOXP3 protein, humanLipopolysaccharidesMicroRNAsmirn199 microRNA, humanNLRP1 protein, humanNLR ProteinsAcute lung injuryCtBP2FOXP3microRNAmiR-199a-3pNLRP1

Identifiers

PMID31754335
PMCPMC6854378
OpenAlexW2975095250

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.