ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2018
Intermolecular Stereoselective Iridium-Catalyzed Allylic Alkylation: An Evolutionary Account.
Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cobalt-Catalyzed Decarboxylative Allylations: Development and Mechanistic Studies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Development of Immobilized Carreira (Phosphoramidite, Olefin) Ligands and Application in Iridium-Catalyzed Asymmetric Allylic Amination.The Journal of organic chemistry · 2023Article
- Enantioselective and Diastereodivergent Allylation of Propargylic C-H Bonds.Journal of the American Chemical Society · 2022Article
- Ir-Catalyzed Asymmetric Allylic Alkylation of Dialkyl Malonates Enabling the Construction of Enantioenriched All-Carbon Quaternary Centers.Journal of the American Chemical Society · 2022Article
- Recent Advances in Enantioselective Pd-Catalyzed Allylic Substitution: From Design to Applications.Chemical reviews · 2021Article
- Controllable, Sequential, and Stereoselective C-H Allylic Alkylation of Alkenes.Journal of the American Chemical Society · 2019Article
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3 authors.
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Abstract
Our lab has long been interested in the development of methods for the creation of enantioenriched all-carbon quaternary stereocenters. Historically, our interest has centered on palladium-catalyzed allylic alkylation, though recent efforts have moved to include the study of iridium catalysts. Whereas palladium catalysts enable the preparation of isolated stereocenters, the use of iridium catalysts allows for the direct construction of vicinal stereocenters via an enantio-, diastereo-, and regioselective allylic alkylation. This account details the evolution of our research program from inception, which focused on the first iridium-catalyzed allylic alkylation to prepare stereodyads containing a single quaternary center, to our most recent discovery that allows for the synthesis of vicinal quaternary centers.
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