Evidence map›Paper›PMID 31754273›Full record

ArticleNature microbiology2019

In vivo structure of the Legionella type II secretion system by electron cryotomography.

Debnath Ghosal, Ki Woo Kim, Huaixin Zheng, Mohammed Kaplan, Hilary K Truchan, Alberto E Lopez, Ian E McIntire, Joseph P Vogel, Nicholas P Cianciotto, Grant J Jensen

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Mucin stimulates the growth ofMicrobiology (Reading, England) · 2026
    Article
  4. Article
  5. Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026
    Review
  6. Article
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  8. Review
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  11. Article
  12. Review
  13. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. Peptidoglycan deacetylation controls type IV secretion and the intracellular survival of the bacterial pathogenProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Debnath GhosalDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Ki Woo KimDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Huaixin ZhengDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mohammed KaplanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Hilary K TruchanDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Alberto E LopezDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ian E McIntireDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Joseph P VogelDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8054-5021
Nicholas P CianciottoDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Grant J JensenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. jensen@caltech.edu.ORCID http://orcid.org/0000-0003-1556-4864
Northwestern University · USCalifornia Institute of Technology · USWashington University in St. Louis · US

Funding

Mentoring For Success: Developing Fundamental Skills For Biomedical ResearchR25GM079300 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCGEE, RICHARD · 2007 to 2020
$6.6M
TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTIONR01AI043987 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIANCIOTTO, NICHOLAS P · 1999 to 2017
$4.8M
Structure and Function of Pathogenesis-Associated Bacterial Structures by Electron CryotomographyR01AI127401 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRANT J JENSEN · 2016 to 2026
$3.9M
NIAID NIH HHS R01 AI043987NIAID NIH HHS R01 AI127401NIAID NIH HHS T32 AI007476NIGMS NIH HHS R25 GM079300
6 · The paper itself

Abstract

The type II secretion system (T2SS) is a multiprotein envelope-spanning assembly that translocates a wide range of virulence factors, enzymes and effectors through the outer membrane of many Gram-negative bacteria

Indexed as

Bacterial ProteinsCryoelectron MicroscopyFimbriae, BacterialLegionella pneumophilaModels, MolecularType II Secretion SystemsVirulence FactorsBacterial ProteinsType II Secretion SystemsVirulence Factors

Identifiers

PMID31754273
PMCPMC6879910
OpenAlexW2991131256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.