Evidence map›Paper›PMID 31754242›Full record

ArticleScientific reports2019

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.

Nancy T Malintan, Steven D Buckingham, David A Lomas, David B Sattelle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Secretion of functional α1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nancy T MalintanCentre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, 5 University Street, London, WC1E 6JF, UK.
Steven D BuckinghamCentre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, 5 University Street, London, WC1E 6JF, UK.
David A LomasCentre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, 5 University Street, London, WC1E 6JF, UK.
David B SattelleCentre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, 5 University Street, London, WC1E 6JF, UK. d.sattelle@ucl.ac.uk.
University College London · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council MR/N024842/1
6 · The paper itself

Abstract

A possible role for calcium signalling in the autosomal dominant form of dementia, familial encephalopathy with neuroserpin inclusion bodies (FENIB), has been proposed, which may point towards a mechanism by which cells could sense and respond to the accumulation of mutant serpin polymers in the endoplasmic reticulum (ER). We therefore explored possible defects in Ca

Indexed as

alpha 1-AntitrypsinAnimalsCalciumCalcium SignalingCHO CellsCricetulusEpilepsies, MyoclonicHeredodegenerative Disorders, Nervous SystemHumansMicroscopy, ConfocalMutationOptical Imagingalpha 1-AntitrypsinCalciumSERPINA1 protein, human

Identifiers

PMID31754242
PMCPMC6872872
OpenAlexW2991242178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.