Evidence map›Paper›PMID 31754227›Full record

ArticleScientific reports2019

Impact of Sex on Office White Coat Effect Tail: Investigating Two Italian Residential Cohorts.

Xavier Humbert, Sophie Fedrizzi, Joachim Alexandre, Alessandro Menotti, Alain Manrique, Martino Laurenzi, Emmanuel Touzé, Paolo E Puddu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Sex Differences in the Usefulness of Unattended Blood Pressure Measurement in Patients with Arterial Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Observational
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xavier HumbertNormandie Université, UNICAEN, Département de médecine générale, 14000, Caen, France.
Sophie FedrizziNormandie Université, UNICAEN, EA 4650, Signalisation, électrophysiologie et imagerie des lésions d'ischémie reperfusion myocardique, 14000, Caen, France.
Joachim AlexandreNormandie Université, UNICAEN, EA 4650, Signalisation, électrophysiologie et imagerie des lésions d'ischémie reperfusion myocardique, 14000, Caen, France.
Alessandro MenottiAssociation for Cardiac Research, 00198, Rome, Italy.
Alain ManriqueNormandie Université, UNICAEN, EA 4650, Signalisation, électrophysiologie et imagerie des lésions d'ischémie reperfusion myocardique, 14000, Caen, France.
Martino LaurenziCentro Studi Epidemiologici di Gubbio (CeSEG), 06024, Gubbio (Perugia), Italy.
Emmanuel TouzéNormandie Université, UNICAEN, Inserm U1237, CHU Caen Normandie, Service de Neurologie, 14000, Caen, France.
Paolo E PudduNormandie Université, UNICAEN, EA 4650, Signalisation, électrophysiologie et imagerie des lésions d'ischémie reperfusion myocardique, 14000, Caen, France. puddu.pe@gmail.com.ORCID http://orcid.org/0000-0002-6191-7838
Normandie Université · FRInserm · FRItalian Association for Cancer Research · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the impact of sex on office white-coat effect tail (OWCET), the waning of systolic blood pressure (SBP) after its waxing during office visit, on the incidence of long-term major fatal and non-fatal events in two Italian residential cohorts [from the Gubbio Study and the Italian Rural Areas of the Seven Countries Study (IRA)]. There were 3565 persons (92 with missing data, 44% men, 54 ± 11 years) included in the Gubbio and 1712 men (49 ± 5 years) in the IRA studies. OWCET was defined as a decrease of ≥10 mmHg in SBP between successive measurements with slight measurement differences between the two cohorts. Cardiovascular (CVD), coronary heart disease (CHD) and stroke (STR) incidences were considered. Over an approximately 20-year follow-up, women with OWCET had an increased risk of CVD [HR: 1.591 (95%CI: 1.204-2.103)], CHD [HR: 1.614 (95%CI: 1.037-2.512)] and STR [HR: 1.696 (95%CI: 1.123-2.563)] events independently of age, serum and HDL cholesterol, cigarettes, BMI and SBP in the Gubbio study. However, there was no increased risk of CVD, CHD or STR in men with OWCET neither in the Gubbio 20-year follow-up nor in the IRA 50-year follow-up. These results were not modified significantly by the correction of the regression dilutions bias between the first and the subsequent SBP measurements. Thus, in primary care, OWCET should be actively evaluated in women as it can improve stratification of long-term CVD, CHD and STR risks.

Indexed as

Blood PressureCause of DeathCholesterol, HDLCohort StudiesCoronary DiseaseFemaleHumansIncidenceItalyMaleMiddle AgedOffice VisitsRisk FactorsStrokeCholesterol, HDL

Identifiers

PMID31754227
PMCPMC6872870
OpenAlexW2991299332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.