Evidence map›Paper›PMID 31754221›Full record

ArticleNature communications2019

Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity.

Cheng Zong, Ranjith Premasiri, Haonan Lin, Yimin Huang, Chi Zhang, Chen Yang, Bin Ren, Lawrence D Ziegler, Ji-Xin Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Bond-Selective Imaging at the Frontier of Biomedicine.Chemical & biomedical imaging · 2025
    Article
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  16. Principle of Stimulated Raman Scattering Microscopy: Emerging at High Spatiotemporal Limits.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng ZongDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Ranjith PremasiriDepartment of Chemistry, Boston University, Boston, MA, 02215, USA.
Haonan LinDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Yimin HuangDepartment of Chemistry, Boston University, Boston, MA, 02215, USA.
Chi ZhangDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Chen YangDepartment of Chemistry, Boston University, Boston, MA, 02215, USA.
Bin RenState Key Laboratory of Physical Chemistry of Solid Surfaces, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China.ORCID http://orcid.org/0000-0002-9821-5864
Lawrence D ZieglerDepartment of Chemistry, Boston University, Boston, MA, 02215, USA.
Ji-Xin ChengDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA. jxcheng@bu.edu.

Funding

Rapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7M
High-throughput high-content single cell analysis by multichannel stimulatedRaman flow cytometryR01GM118471 · NIGMS · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2016 to 2019
$1.6M
NIAID NIH HHS R01 AI141439NIGMS NIH HHS R01 GM118471
6 · The paper itself

Abstract

Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM for endogenous biomolecules. Electronic pre-resonant SRS allows detection of sub-micromolar chromophores. However, label-free SRS detection of single biomolecules having extremely small Raman cross-sections (~10

Indexed as

LasersAdenineElectronsNitrogen IsotopesNonlinear Optical MicroscopyReproducibility of ResultsSingle Molecule ImagingSpectrum Analysis, RamanStaphylococcus aureusStress, PhysiologicalAdenineNitrogen Isotopes

Identifiers

PMID31754221
PMCPMC6872561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.