ArticleNature communications2019
NAD
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.
0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
183 citing papers in PubMed, 267 citations in OpenAlex.
- Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.Aging cell · 2025Trial
- Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025Trial
- Trial
- Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Scientific reports · 2022Trial
- Article
- Mitophagy in neuronal health and disease: from mechanisms to neurodegeneration.The Journal of clinical investigation · 2026Review
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- Article
- Targeting mtDNA to Modulate Mitochondrial Dysfunction in Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Reprogramming Neuroinflammation: Mitochondrial Targets and Immune Checkpoint Inhibitors in Alzheimer's Disease.Molecular neurobiology · 2026Review
- An integrated anti-aging framework targeting NADRedox biology · 2026Review
- The role of gut microbiota-mitochondria crosstalk in neurodegeneration: Underlying mechanisms and potential therapies.Neural regeneration research · 2026Article
- Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging.npj aging · 2026Article
- Organelle resilience as a comparative blueprint for longevity.EMBO molecular medicine · 2026Review
- Mitochondria at the heart of aging: structure, function, and failure.Journal of translational medicine · 2026Review
- Effects of NAD⁺ repletion with Nicotinamide riboside on obesity-induced chronic kidney disease and renal cell lipotoxicity.Scientific reports · 2026Article
- Treatment of age-related decreases in GTP levels restores endocytosis and autophagy.GeroScience · 2026Article
- Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach.GeroScience · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 9 institutions in 6 countries.
Evandro F FangLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA. e.f.fang@medisin.uio.no.ORCID http://orcid.org/0000-0003-0355-7202
Yujun HouLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0003-1778-1176
Sofie LautrupDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.ORCID http://orcid.org/0000-0002-6632-7853
Martin Borch JensenBuck Institute for Research on Aging, Novato, CA, 94945, USA.
Beimeng YangLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Tanima SenGuptaDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Domenica CaponioDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.ORCID http://orcid.org/0000-0002-3827-8943
Rojyar KhezriDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379, Oslo, Norway.
Tyler G DemarestLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Yahyah AmanDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
David FigueroaLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Marya MorevatiLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Ho-Joon LeeDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-3616-5387
Hisaya KatoClinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.ORCID http://orcid.org/0000-0002-5964-6856
Henok KassahunLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Jong-Hyuk LeeLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Deborah FilippelliMolecular Toxicology Group, Department of Biology, University of Konstanz, 78457, Konstanz, Germany.
Mustafa Nazir OkurLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Aswin MangerichMolecular Toxicology Group, Department of Biology, University of Konstanz, 78457, Konstanz, Germany.ORCID http://orcid.org/0000-0001-9742-2338
Deborah L CroteauLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Yoshiro MaezawaClinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0001-9309-6141
Jun TaoDepartment of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, China.
Koutaro YokoteClinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Tor Erik RustenDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379, Oslo, Norway.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0002-9816-4155
Heinrich JasperBuck Institute for Research on Aging, Novato, CA, 94945, USA.
Hilde NilsenDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Vilhelm A BohrLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA. bohrv@grc.nia.nih.gov.ORCID http://orcid.org/0000-0003-4823-6429
National Institutes of Health · USUniversity of Oslo · NOChiba University · JPBuck Institute for Research on Aging · USOslo University Hospital · NOUniversity of Copenhagen · DKUniversity of Konstanz · DEUniversity of Michigan · USSun Yat-sen University · CN
Funding
Statistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MNIDDK NIH HHS U24 DK097153
Abstract
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic deficit can be targeted for therapeutic intervention has not been determined. Here we report impaired mitophagy and depletion of NAD
Indexed as
MitophagyAging, PrematureAnimalsAutophagy-Related Protein-1 HomologCaenorhabditis elegansCation Transport ProteinsDisease Models, AnimalDrosophila melanogasterHumansIntracellular Signaling Peptides and ProteinsMutationNADNicotinamide-Nucleotide AdenylyltransferaseSolute Carrier Family 11, Member 2Werner SyndromeWerner Syndrome HelicaseAutophagy-Related Protein-1 HomologCation Transport ProteinsIntracellular Signaling Peptides and ProteinsNADNicotinamide-Nucleotide AdenylyltransferaseNMNAT1 protein, humanSolute Carrier Family 11, Member 2ULK1 protein, humanWerner Syndrome Helicase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.