Evidence map›Paper›PMID 31754099›Full record

ArticleNature communications2019

Brain activity regulates loose coupling between mitochondrial and cytosolic Ca

Yuan Lin, Lin-Lin Li, Wei Nie, Xiaolei Liu, Avital Adler, Chi Xiao, Fujian Lu, Liping Wang, Hua Han, Xianhua Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Mitochondrial CaNature metabolism · 2026
    Article
  4. Mitochondrial CaBiomolecules · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Electron Microscopic Mapping of Mitochondrial Morphology in the Cochlear Nerve Fibers.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Mitochondrial CaBiomedicines · 2022
    Review
  16. Dynamic Regulation of Mitochondrial [CaInternational journal of molecular sciences · 2022
    Article
  17. Mitochondrial CaCommunications biology · 2022
    Article
  18. Review
  19. IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yuan LinState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, 100871, China.ORCID http://orcid.org/0000-0001-9147-8031
Lin-Lin LiNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Wei NieState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
Xiaolei LiuThe Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Avital AdlerSkirball Institute of Biomolecular Medicine, Department of Neuroscience and Physiology, Department of Anesthesiology, Neuroscience Institute, New York University School of Medicine, New York, NY, 10016, USA.
Chi XiaoNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Fujian LuState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
Liping WangThe Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Hua HanNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Xianhua WangState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
Wen-Biao GanSkirball Institute of Biomolecular Medicine, Department of Neuroscience and Physiology, Department of Anesthesiology, Neuroscience Institute, New York University School of Medicine, New York, NY, 10016, USA. Wenbiao.Gan@nyulangone.org.
Heping ChengState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, 100871, China. chengp@pku.edu.cn.
Chinese Academy of Sciences · CNPeking University · CNNeurosciences Institute · USNew York University · US

Funding

Experience-dependent plasticity of synaptic structure.-Resubmission-1R01NS047325 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAO, MOSES VICTOR · 2004 to 2019
$6.2M
In vivo studies of microglial functions in brain plasticity and pathologyR01NS087198 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GAN, WENBIAO · 2014 to 2018
$1.9M
Stress hormone, calcium spikes and synapse loss in Alzheimer’s diseaseR21AG061751 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAO, MOSES VICTOR, GAN, WENBIAO · 2019 to 2020
$466k
NIA NIH HHS R21 AG061751NINDS NIH HHS R01 NS047325NINDS NIH HHS R01 NS087198
6 · The paper itself

Abstract

Mitochondrial calcium ([Ca

Indexed as

Calcium SignalingAnimalsBrainCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CytosolMice, Inbred C57BLMicroscopy, Electron, ScanningMicroscopy, Fluorescence, MultiphotonMitochondriaMotor CortexNeuronsVisual CortexCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2

Identifiers

PMID31754099
PMCPMC6872662
OpenAlexW2990194524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.