Evidence map›Paper›PMID 31754032›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.

Yann Desfougères, Miranda S C Wilson, Debabrata Laha, Gregory J Miller, Adolfo Saiardi

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  7. The inositol pyrophosphate 5-InsPThe Journal of biological chemistry · 2026
    Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yann DesfougèresMedical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT London, United Kingdom.ORCID 0000-0002-6450-5863
Miranda S C WilsonMedical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT London, United Kingdom.
Debabrata LahaMedical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT London, United Kingdom.
Gregory J MillerDepartment of Chemistry, The Catholic University of America, Washington, DC 20064.
Adolfo SaiardiMedical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT London, United Kingdom; a.saiardi@ucl.ac.uk.ORCID 0000-0002-4351-0081
MRC Laboratory for Molecular Cell Biology · GBUniversity of America · US

Funding

Integration of Phosphatidylinositol and Diphosphoinositol Signals at the ExocystR15GM106322 · NIGMS · CATHOLIC UNIVERSITY OF AMERICA · PI MILLER, GREGORY JAMES · 2015 to 2015
$239k
Medical Research Council MC_UU_00012/4Medical Research Council MC_UU_12018/4Medical Research Council MC_UU12018/4NIGMS NIH HHS R15 GM106322
6 · The paper itself

Abstract

Inositol phosphates (IPs) comprise a network of phosphorylated molecules that play multiple signaling roles in eukaryotes. IPs synthesis is believed to originate with IP

Indexed as

Amino Acid SequenceArchaeal ProteinsConserved SequenceHCT116 CellsHumansHydrolysisInositolInositol PhosphatesPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiaeSphingolipidsType C PhospholipasesArchaeal ProteinsInositolInositol Phosphatesinositol-tetrakisphosphate 1-kinaseITPK1 protein, humanPhosphotransferases (Alcohol Group Acceptor)SphingolipidsType C Phospholipasesglucoseinositol phosphatemetabolismphosphatephospholipase C

Identifiers

PMID31754032
PMCPMC6900528
OpenAlexW2989629836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.