Evidence map›Paper›PMID 31754028›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Neogenin-1 distinguishes between myeloid-biased and balanced

Gunsagar S Gulati, Monika Zukowska, Joseph J Noh, Allison Zhang, Daniel J Wesche, Rahul Sinha, Benson M George, Irving L Weissman, Krzysztof Szade

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. CCR5 marks a subset of mouse hematopoietic stem cells that are myeloid primed and expand with age.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Monocyte-Macrophage Lineage Cell Fusion.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Gunsagar S GulatiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.ORCID 0000-0003-2798-6220
Monika ZukowskaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Joseph J NohInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Allison ZhangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Daniel J WescheInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Benson M GeorgeInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305; irv@stanford.edu krzysztof.szade@uj.edu.pl.
Krzysztof SzadeInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305; irv@stanford.edu krzysztof.szade@uj.edu.pl.
California Institute for Regenerative Medicine · USJagiellonian University · PL

Funding

Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
Stem Cell Biology, Cancer Stem Cell Biology, and Cancer ImmunotherapyR35CA220434 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2023
$6.7M
Cellular and molecular analyses of hematopoietic stem cell [HSC] interactions with bone marrow niches to improve HSC engraftment for transplantation and tolerance inductionR01DK115600 · NIDDK · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2018 to 2021
$1.5M
Investigating the role of the Neogenin-1/Netrin-1 axis in aging and lineage bias of hematopoietic stem cells (HSCs)F30HL147460 · NHLBI · STANFORD UNIVERSITY · PI GULATI, GUNSAGAR SINGH · 2019 to 2020
$89k
NCI NIH HHS R35 CA220434NCI NIH HHS T32 CA009302NHLBI NIH HHS F30 HL147460NIDDK NIH HHS R01 DK115600
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) self-renew and generate all blood cells. Recent studies with single cell transplants and lineage tracing suggest that adult HSCs are diverse in their reconstitution and lineage potentials. However, prospective isolation of these subpopulations has remained challenging. Here, we identify Neogenin-1 (NEO1) as a unique surface marker on a fraction of mouse HSCs labeled with

Indexed as

AgingAnimalsFemaleHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHomeodomain ProteinsMembrane ProteinsMiceMice, TransgenicHomeodomain ProteinsHoxb5 protein, mouseMembrane Proteinsneogeninaginghematopoietic stem cellmyeloid biasNeogenin-1transplantation

Identifiers

PMID31754028
PMCPMC6911217
OpenAlexW2990354144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.