Evidence map›Paper›PMID 31754022›Full record

ArticleGenome research2019

Identifying gene function and module connections by the integration of multispecies expression compendia.

Hao Li, Daria Rukina, Fabrice P A David, Terytty Yang Li, Chang-Myung Oh, Arwen W Gao, Elena Katsyuba, Maroun Bou Sleiman, Andrea Komljenovic, Qingyao Huang and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Hao LiLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0001-5677-3377
Daria RukinaInstitute of Mathematics, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Fabrice P A DavidGene Expression Core Facility, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Terytty Yang LiLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Chang-Myung OhLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Arwen W GaoLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Elena KatsyubaLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Maroun Bou SleimanLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Andrea KomljenovicSwiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Qingyao HuangLaboratory of Metabolic Signaling, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee, Memphis, Tennessee 38163, USA.
Marc Robinson-RechaviSwiss Institute of Bioinformatics, Lausanne 1015, Switzerland.ORCID 0000-0002-3437-3329
Kristina SchoonjansLaboratory of Metabolic Signaling, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Stephan MorgenthalerInstitute of Mathematics, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Johan AuwerxLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0002-5065-5393
École Polytechnique Fédérale de Lausanne · CHSIB Swiss Institute of Bioinformatics · CHUniversity of Tennessee Health Science Center · US

Funding

Translational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5M
NIA NIH HHS R01 AG043930
6 · The paper itself

Abstract

The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First,

Indexed as

Databases, Nucleic AcidGene Expression ProfilingGene Expression Regulation, FungalGene Regulatory NetworksSoftwareAnimalsHumansMiceRatsSaccharomyces cerevisiae

Identifiers

PMID31754022
PMCPMC6886503
OpenAlexW2990465161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.