Evidence map›Paper›PMID 31754016›Full record

ArticleGenetics2020

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in

Erica L Macke, Erika Henningsen, Erik Jessen, Nicholas A Zumwalde, Michael Landowski, Daniel E Western, Wei-Hua Lee, Che Liu, Nathan P Gruenke, Anna-Lisa Doebley and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Airway macrophage specific glycocalyx expression and remodeling following viral infection.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Endothelial glycocalyx in retina, hyperglycemia, and diabetic retinopathy.American journal of physiology. Cell physiology · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. An Overview ofFrontiers in cell and developmental biology · 2021
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Erica L MackeDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.ORCID 0000-0001-8324-506X
Erika HenningsenDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Erik JessenDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Nicholas A ZumwaldeDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Wisconsin 53706.
Michael LandowskiDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Daniel E WesternDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Wei-Hua LeeDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Che LiuInstitute for Molecular Virology, University of Wisconsin-Madison, Wisconsin 53706.
Nathan P GruenkeDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Anna-Lisa DoebleyDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Samuel MillerDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Bikash PattnaikDepartment of Pediatrics, University of Wisconsin-Madison, Wisconsin 53706.ORCID 0000-0002-5385-358X
Sakae IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Jenny E GumperzDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Wisconsin 53706.ORCID 0000-0003-1852-2192
Akihiro IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706 aikeda@wisc.edu.ORCID 0000-0001-8440-3891
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
Molecular Genetics of Age-Dependent Retinal DegenerationR01EY022086 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2012 to 2026
$6.1M
Functional Genomics of Stress Defense in YeastR01GM083989 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2008 to 2016
$3.0M
Molecular Therapies for Lebers Congenital Amaurosis Caused by KCNJ13 MutationsR01EY024995 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PATTNAIK, BIKASH RANJAN · 2015 to 2018
$1.5M
Role of chondroitin sulfate proteoglycans in photoreceptor - RPE interactionR21EY029067 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI IKEDA, AKIHIRO · 2018 to 2019
$414k
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY022086NEI NIH HHS R01 EY024995NEI NIH HHS R21 EY029067NIGMS NIH HHS T32 GM007133NIGMS NIH HHS T32 GM007266NIH HHS S10 OD023526
6 · The paper itself

Abstract

One major aspect of the aging process is the onset of chronic, low-grade inflammation that is highly associated with age-related diseases. The molecular mechanisms that regulate these processes have not been fully elucidated. We have identified a spontaneous mutant mouse line, small with kinky tail (

Indexed as

Protein Processing, Post-TranslationalAge FactorsAnimalsApoptosisChondroitin SulfatesFemaleGlucuronosyltransferaseInflammationMaleMiceMice, Inbred C57BLMice, KnockoutMultifunctional EnzymesMutationN-AcetylgalactosaminyltransferasesNeurodegenerative DiseasesChondroitin SulfatesChsy1 protein, mouseGlucuronosyltransferaseMultifunctional EnzymesN-AcetylgalactosaminyltransferasesProteinsSkt protein, mouseagingchondroitin sulfate synthasehippocampusinflammationmousemyeloid cellsneurodegenerationretinaretinal pigment epitheliumsubretinal space

Identifiers

PMID31754016
PMCPMC6944401
OpenAlexW2990893082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.