ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Flexible Coupling of Synaptic and Intrinsic Plasticity in a Cerebellar Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Branch-specific clustered parallel fiber input controls dendritic computation in Purkinje cells.iScience · 2024Article
- Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nature communications · 2024Article
- Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.PLoS computational biology · 2024Article
- Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology.Brain sciences · 2022Review
- Protein kinase Cγ in cerebellar Purkinje cells regulates CaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex.Current research in neurobiology · 2022Article
- Immune-Triggered Forms of Plasticity Across Brain Regions.Frontiers in cellular neuroscience · 2022Review
- Psychosis symptoms following aberrant immunity in the brain.Neural regeneration research · 2021Article
- Article
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1 author.
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Abstract
The role of dendrites in the integration of widespread synaptic activity has been studied in experiments and theories (Johnston et al., 1996; Magee, 2007). However, whether the conduction of synaptic currents from dendrites to the soma depends on excitability of those dendritic branches is unclear. How modulation of the branch excitability affects the conduction of synaptic inputs and their selection on dendrites is also elusive. Here, I performed simultaneous voltage-clamp recordings from the soma and dendrites of single cerebellar Purkinje neurons in male Sprague-Dawley rats and analyzed the relationship between spontaneous EPSCs on both sides. I found that EPSCs on distal dendrites have a salient discordance in amplitude compared with those on the soma. Furthermore, individual ratios of the EPSC concurrently recorded on the soma and dendrites were not unique, but discrete, suggesting the occurrence of various attenuations in different paths of dendritic branches to the soma. The obtained data and simulations indicate several distinct groups (4.5 ± 0.3,
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