Evidence map›Paper›PMID 31753916›Full record

ArticleThe Journal of biological chemistry2019

The RNA-binding protein FMRP facilitates the nuclear export of

Phillip J Hsu, Hailing Shi, Allen C Zhu, Zhike Lu, Nimrod Miller, Brittany M Edens, Yongchao C Ma, Chuan He

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 135 citations in OpenAlex.

  1. Review
  2. FMRP promotes gastric cancer progression via mJournal of translational medicine · 2026
    Article
  3. The mMolecular psychiatry · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. mEpigenomes · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Loss of age-associated increase in mbioRxiv : the preprint server for biology · 2025
    Article
  15. mAutism research : official journal of the International Society for Autism Research · 2025
    Article
  16. Review
  17. Targeting mCurrent oncology (Toronto, Ont.) · 2025
    Review
  18. Review
  19. Review
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Phillip J HsuDepartment of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Hailing ShiDepartment of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Allen C ZhuDepartment of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Zhike LuDepartment of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Nimrod MillerDepartments of Pediatrics, Neurology and Physiology, Northwestern University Feinberg School of Medicine, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.
Brittany M EdensDepartments of Pediatrics, Neurology and Physiology, Northwestern University Feinberg School of Medicine, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.
Yongchao C MaDepartments of Pediatrics, Neurology and Physiology, Northwestern University Feinberg School of Medicine, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611 ma@northwestern.edu.ORCID 0000-0002-2469-4356
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637 chuanhe@uchicago.edu.
Howard Hughes Medical Institute · USNorthwestern University · US

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Regulation of Mitochondrial Function and Motor Neuron Degeneration in SMAR01NS094564 · NINDS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI MA, YONGCHAO CHARLES · 2015 to 2019
$1.6M
Rescuing Motor Neuron Mitochondrial Defects in SMA by Mitigating Cdk5 ActivationR21NS106307 · NINDS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI MA, YONGCHAO CHARLES · 2018 to 2019
$421k
The Effects of ERK2-Induced Phosphorylation of METTL3 on N6-methyladenosine (m6A) mRNA Methylation in MelanomaF30CA247175 · NCI · UNIVERSITY OF CHICAGO · PI ZHU, ALLEN C · 2020 to 2023
$192k
NCI NIH HHS F30 CA247175NIGMS NIH HHS T32 GM007281NINDS NIH HHS R01 NS094564NINDS NIH HHS R21 NS106307
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Active Transport, Cell NucleusAdenosineAnimalsBinding SitesCell NucleusCerebral CortexFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutRNA InterferenceRNA, MessengerRNA, Small InterferingAdenosineFMR1 protein, humanFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1N-methyladenosineRNA, MessengerRNA, Small InterferingFmr1 KO miceFMRPfragile X mental retardation protein (FMRP)gene regulationmousemouse brainN6-methyladenosine (m6A)neurological diseasenuclear RNAnuclear RNA exportpost-transcriptional modificationRNA-binding proteinRNA metabolismRNA methylation

Identifiers

PMID31753916
PMCPMC6937581
OpenAlexW2991175285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.