Evidence map›Paper›PMID 31753914›Full record

ArticleGenes & development2019

Paralytic, the

Beverly J Piggott, Christian J Peters, Ye He, Xi Huang, Susan Younger, Lily Yeh Jan, Yuh Nung Jan

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Natural noncodingScience advances · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Ion Channels in Gliomas-From Molecular Basis to Treatment.International journal of molecular sciences · 2023
    Review
  6. Voltage-gated sodium channelProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Neural Signaling in Cancer.Annual review of neuroscience · 2022
    Review
  8. KProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk.Reviews of physiology, biochemistry and pharmacology · 2022
    Review
  10. Article
  11. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Beverly J PiggottDepartment of Physiology, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA.
Christian J PetersDepartment of Physiology, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA.
Ye HeNeuroscience Initiative, Advanced Science Research Center, the Graduate Center, City University of New York, New York 10031, New York.
Xi HuangProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
Susan YoungerDepartment of Physiology, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA.
Lily Yeh JanDepartment of Physiology, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA.
Yuh Nung JanDepartment of Physiology, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA.
University of California, San Francisco · USHoward Hughes Medical Institute · USCUNY Advanced Science Research Center · USUniversity of Toronto · CA

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK · 2014 to 2026
$13.5M
Dendrite morphogenesis, function and regenerationR35NS097227 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2017 to 2024
$5.1M
Neurons of the medial habenula regulate behavioral responses to nicotine in mouseK99DA041500 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETERS, CHRISTIAN · 2017 to 2018
$307k
Howard Hughes Medical InstituteNIDA NIH HHS K99 DA041500NIH HHS P40 OD018537NINDS NIH HHS R35 NS097227
6 · The paper itself

Abstract

Proliferating cells, typically considered "nonexcitable," nevertheless, exhibit regulation by bioelectric signals. Notably, voltage-gated sodium channels (VGSC) that are crucial for neuronal excitability are also found in progenitors and up-regulated in cancer. Here, we identify a role for VGSC in proliferation of

Indexed as

AnimalsApoptosisCell CountCell LineageCell ProliferationDrosophilaDrosophila ProteinsGene ExpressionGene Knockdown TechniquesNeural Stem CellsSodium ChannelsDrosophila Proteinspara protein, DrosophilaSodium Channelscancer biologydevelopmentdrosophilaneuroscienceproliferationstem cells

Identifiers

PMID31753914
PMCPMC6942049
OpenAlexW2990604301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.