ArticleBMJ open2019
Existing comorbidities in people with osteoarthritis: a retrospective analysis of a population-based cohort in Alberta, Canada.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
- Exploratory Cross-Trial Non-Inferiority Analysis of 2% Versus 1% Sodium Hyaluronate in Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Association between symptomatic knee osteoarthritis and health-related quality of life in individuals with type 2 diabetes: A cross-sectional study.Osteoarthritis and cartilage open · 2026Article
- The role of the immune system in osteoarthritis: mechanisms, challenges and future directions.Nature reviews. Rheumatology · 2025Review
- Review
- Strategies to Improve Equitable Access to Early Osteoarthritis Diagnosis and Management: An Updated Review.Arthritis care & research · 2025Review
- Association between ethylene oxide exposure and osteoarthritis risk among middle-aged and young adults: a cross-sectional study.Frontiers in public health · 2025Article
- Green Light Exposure Reduces Primary Hyperalgesia and Proinflammatory Cytokines in a Rodent Model of Knee Osteoarthritis: Shedding Light on Sex Differences.Biomedicines · 2024Article
- Policies in Canada fail to address disparities in access to person-centred osteoarthritis care: a content analysis.BMC health services research · 2024Article
- Clinical phenotypes of comorbidities in end-stage knee osteoarthritis: a cluster analysis.BMC musculoskeletal disorders · 2024Article
- Demographic, health, physical activity, and workplace factors are associated with lower healthy working life expectancy and life expectancy at age 50.Scientific reports · 2024Article
- Prevalence and Predictors of Depression in Women with Osteoarthritis: Cross-Sectional Analysis of Nationally Representative Survey Data.Healthcare (Basel, Switzerland) · 2024Article
- Priority strategies to reduce socio-gendered inequities in access to person-centred osteoarthritis care: Delphi survey.BMJ open · 2024Article
- Global, regional, and national burdens of osteoarthritis from 1990 to 2021: findings from the 2021 global burden of disease study.Frontiers in medicine · 2024Article
- Work-related outcomes in individuals with and without lower limb osteoarthritis: an online survey.BMC public health · 2023Article
- The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study).BMC musculoskeletal disorders · 2023Article
- Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data.Arthritis research & therapy · 2023Article
- Modeling the Impact of Meniscal Tears on von Mises Stress of Knee Cartilage Tissue.Bioengineering (Basel, Switzerland) · 2023Article
- Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders.Depression and anxiety · 2023Article
- Rural-Urban Disparities in Realized Spatial Access to General Practitioners, Orthopedic Surgeons, and Physiotherapists among People with Osteoarthritis in Alberta, Canada.International journal of environmental research and public health · 2022Article
- Decline of Lung Function in Knee and Spine Osteoarthritis in the Korean Population: Cross-Sectional Analysis of Data from the Korea National Health and Nutrition Examination Survey.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe purpose of this study is to estimate the prevalence of comorbidities among people with osteoarthritis (OA) using administrative health data.
designRetrospective cohort analysis.
settingAll residents in the province of Alberta, Canada registered with the Alberta Health Care Insurance Plan population registry.
participants497 362 people with OA as defined by 'having at least one OA-related hospitalization, or at least two OA-related physician visits or two ambulatory care visits within two years'. PRIMARY OUTCOME MEASURES: We selected eight comorbidities based on literature review, clinical consultation and the availability of validated case definitions to estimate their frequencies at the time of diagnosis of OA. Sex-stratified age-standardised prevalence rates per 1000 population of eight clinically relevant comorbidities were calculated using direct standardisation with 95% CIs. We applied χ
results54.6% (n=2 71 794) of people meeting the OA case definition had at least one of the eight selected comorbidities. Females had a significantly higher rate of comorbidities compared with males (standardised rates ratio=1.26, 95% CI 1.25 to 1.28). Depression, chronic obstructive pulmonary disease (COPD) and hypertension were the most prevalent in both females and males after age-standardisation, with 40% of all cases having any combination of these comorbidities. We observed a significant difference in the percentage of comorbidities among age groups, illustrated by the youngest age group (<45 years) having the highest percentage of cases with depression (24.6%), compared with a frequency of 16.1% in those >65 years.
conclusionsOur findings highlight the high frequency of comorbidity in people with OA, with depression having the highest age-standardised prevalence rate. Comorbidities differentially affect females, and vary by age. These factors should inform healthcare programme and delivery.
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