ArticleBMJ open2019
Efficacy of
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Growth and neuro-developmental outcomes of probiotic supplemented preterm infants-a systematic review and meta-analysis.European journal of clinical nutrition · 2023Pooled it
- Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants.The Cochrane database of systematic reviews · 2023Pooled it
- Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants: The PRIMAL Randomized Clinical Trial.JAMA pediatrics · 2024Trial
- Trial
- Fecal Microbiota Transplantation (FMT) as a Prophylaxis of Necrotizing Enterocolitis (NEC)-Protocol for a Safety Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Probiotic modulation of the neonatal gut-lung axis in the regulation of early respiratory function.Frontiers in cellular and infection microbiology · 2026Article
- Insufficient immune protection in preterm infants due to delayed or incomplete hexavalent vaccination.Frontiers in immunology · 2025Article
- Effects of multistrain Bifidobacteria and Lactobacillus probiotics on HMO compositions after supplementation to pregnant women at threatening preterm delivery: design of the randomized clinical PROMO trial.Molecular and cellular pediatrics · 2024Review
- γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis.The Journal of experimental medicine · 2024Article
- Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis.CNS neuroscience & therapeutics · 2024Review
- Early-life microbiota-immune homeostasis.Frontiers in immunology · 2023Review
- Article
- Article
- Comprehensive analysis of 84Frontiers in cellular and infection microbiology · 2022Article
- Current Status of Probiotics for Preterm Infants.Indian journal of pediatrics · 2021Review
- Xylitol enhances synthesis of propionate in the colon via cross-feeding of gut microbiota.Microbiome · 2021Article
- Effects of neonatal nutrition interventions on neonatal mortality and child health and development outcomes: A systematic review.Campbell systematic reviews · 2021Review
- L-Arginine Modulates Neonatal Leukocyte Recruitment in a Gestational Age-Dependent Manner.Journal of clinical medicine · 2020Article
- Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe healthy 'eubiosis' microbiome in infancy is regarded as the microbiome derived from term, vaginally delivered, antibiotic free, breastfed infants at 4-6 months. Dysbiosis is regarded as a deviation from a healthy state with reduced microbial diversity and deficient capacity to control drug-resistant organisms. Preterm infants are highly sensitive to early gut dysbiosis. Latter has been associated with sepsis and necrotising enterocolitis, but may also contribute to long-term health problems. Probiotics hold promise to reduce the risk for adverse short-term outcomes but the evidence from clinical trials remains inconclusive and none has directly assessed the effects of probiotics on the microbiome at high resolution. METHODS AND ANALYSIS: A randomised, double blind, placebo-controlled study has been designed to assess the safety and efficacy of the probiotic mix of ETHICS AND DISSEMINATION: Ethics approval was obtained in all participating sites. Results of the trial will be published in peer-review journals, at scientific meetings, on the website (www.primal-study.de) and via social media of parent organisations. TRIAL REGISTRATION NUMBER: DRKS00013197; Pre-results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.