Evidence map›Paper›PMID 31753695›Full record

ArticleBioorganic & medicinal chemistry letters2020

In vivo comparison of N-

J S Dileep Kumar, Jaya Prabhakaran, Naresh Damuka, Justin Wayne Hines, Skylar Norman, Meghana Dodda, J John Mann, Akiva Mintz, Kiran Kumar Solingapuram Sai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  2. Article
  3. Development and Optimization ofACS pharmacology & translational science · 2023
    Review
  4. Review
  5. In vivo evaluation of a microtubule PET ligand, [Pharmacological reports : PR · 2022
    Article
  6. Preliminary Evaluations of [Frontiers in neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J S Dileep KumarMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA. Electronic address: dileep.kumar@nyspi.columbia.edu.
Jaya PrabhakaranMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA; Department of Psychiatry, Columbia University Medical Center, New York, USA.
Naresh DamukaMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA.
Justin Wayne HinesDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Skylar NormanDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Meghana DoddaDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
J John MannMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA; Department of Psychiatry, Columbia University Medical Center, New York, USA; Department of Radiology, Columbia University Medical Center, New York, USA.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, USA.
Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA. Electronic address: ksolinga@wakehealth.edu.

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAPP, STEPHEN R · 2016 to 2020
$12.2M
CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's diseaseR01AG065839 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLINGAPURAM SAI, KIRAN · 2020 to 2024
$2.5M
NCATS NIH HHS UL1 TR001420NCATS NIH HHS UM1 TR004929NIA NIH HHS P30 AG049638
6 · The paper itself

Abstract

Altered dynamics of microtubules (MT) are implicated in the pathophysiology of a number of brain diseases. Therefore, radiolabeled MT targeted ligands that can penetrate the blood brain barrier (BBB) may offer a direct and sensitive approach for diagnosis, and assessing the clinical potential of MT targeted therapeutics using PET imaging. We recently reported two BBB penetrating radioligands, [

Indexed as

AnimalsBlood-Brain BarrierBrainCarbon RadioisotopesIsotope LabelingLigandsMiceMicrotubulesPositron-Emission TomographyRadiopharmaceuticalsTissue DistributionCarbon-11Carbon RadioisotopesLigandsRadiopharmaceuticalsBrainMicrotubulePETRadiotracerTubulin

Identifiers

PMID31753695
PMCPMC11659960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.