ArticleJournal of hazardous materials2020
Ultrasensitive and rapid detection of ochratoxin A in agro-products by a nanobody-mediated FRET-based immunosensor.
Article in Journal of hazardous materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- DNAzyme-responsive hydrogel platform integrating Au@Pt@4-MBN nanozyme for dual-mode Ochratoxin A detection.Mikrochimica acta · 2026Article
- Review
- Biosensing strategies using recombinant luminescent proteins and their use for food and environmental analysis.Analytical and bioanalytical chemistry · 2024Review
- Comprehensive Insights into Ochratoxin A: Occurrence, Analysis, and Control Strategies.Foods (Basel, Switzerland) · 2024Review
- Nanoscale Materials Applying for the Detection of Mycotoxins in Foods.Foods (Basel, Switzerland) · 2023Review
- N/S-Co-doped carbon dot-based FRET ratiometric fluorescence aptasensing platform modulated with entropy-driven DNA amplifier for ochratoxin A detection.Analytical and bioanalytical chemistry · 2023Article
- FRET Based Biosensor: Principle Applications Recent Advances and Challenges.Diagnostics (Basel, Switzerland) · 2023Review
- Developments in FRET- and BRET-Based Biosensors.Micromachines · 2022Review
- Article
- A Nanobody-on-Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR).Angewandte Chemie (International ed. in English) · 2022Article
- An Immuno-Separated Assay for Ochratoxin Detection Coupled with a Nano-Affinity Cleaning-Up for LC-Confirmation.Foods (Basel, Switzerland) · 2022Article
- "Ready-to-use" immunosensor for the detection of small molecules with fast readout.Biosensors & bioelectronics · 2022Article
- Recent Progress in Rapid Determination of Mycotoxins Based on Emerging Biorecognition Molecules: A Review.Toxins · 2022Review
- Fluonanobody-based nanosensor via fluorescence resonance energy transfer for ultrasensitive detection of ochratoxin A.Journal of hazardous materials · 2022Article
- Article
- Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis.Archives of toxicology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Ochratoxin A (OTA) is a major concern for public health and the rapid detection of trace OTA in food is always a challenge. To minimize OTA exposure to consumers, a nanobody (Nb)-mediated förster resonance energy transfer (FRET)-based immunosensor using quantum dots (Nb-FRET immunosensor) was proposed for ultrasensitive, single-step and competitive detection of OTA in agro-products at present work. QDs of two sizes were covalently labeled with OTA and Nb, acting as the energy donor and acceptor, respectively. The free OTA competed with the donor to bind to acceptor, thus the FRET efficiency increased with the decrease of OTA concentration. The single-step assay could be finished in 5 min with a limit of detection of 5 pg/mL, which was attributed to the small size of Nb for shortening the effective FRET distance and improving the FRET efficiency. The Nb-FRET immunosensor exhibited high selectivity for OTA. Moreover, acceptable accuracy and precision were obtained in the analysis of cereals and confirmed by the liquid chromatography-tandem mass spectrometry. Thus the developed Nb-FRET immunosensor was demonstrated to be an efficient tool for ultrasensitive and rapid detection of OTA in cereals and provides a detection model for other toxic small molecules in food and environment.
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Registered trials
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