ArticleSchizophrenia research2020
Sleep spindle and slow wave abnormalities in schizophrenia and other psychotic disorders: Recent findings and future directions.
Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Article
- Study protocol for the Danish High Risk and Resilience Study VIA 19 - from age 15 to age 19: transition from adolescence to early adulthood.Frontiers in psychiatry · 2026Article
- Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribution to spindle dynamics.iScience · 2025Article
- Brief sleep disruption following hippocampus-dependent learning downscales interneuron synapses within lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- The Infraslow Fluctuation of Sigma Power During Sleep in Young Individuals with Schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- Lesion network guided delta frequency neuromodulation improves cognition in patients with psychosis spectrum disorders: A pilot study.Asian journal of psychiatry · 2024Article
- Emotional memory consolidation during sleep is associated with slow oscillation-spindle coupling strength in young and older adults.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Adolescent sleep defects and dopaminergic hyperactivity in mice with a schizophrenia-linked Shank3 mutation.Sleep · 2023Article
- Sleep spindles across youth affected by schizophrenia or anti-Frontiers in psychiatry · 2023Article
- Hierarchical fusion detection algorithm for sleep spindle detection.Frontiers in neuroscience · 2023Article
- Relationships between rest-activity rhythms, sleep, and clinical symptoms in individuals at clinical high risk for psychosis and healthy comparison subjects.Journal of psychiatric research · 2022Article
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Article
- A redux of schizophrenia research in 2021.Schizophrenia research · 2022Article
- Developmental oxidative stress leads to T-type CaMolecular psychiatry · 2022Article
- The Danish High-Risk and Resilience Study-VIA 15 - A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls.Frontiers in psychiatry · 2022Article
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3 authors.
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Abstract
Sleep spindles and slow waves are the two main oscillatory activities occurring during NREM sleep. Slow waves are ∼1 Hz, high amplitude, negative-positive deflections that are primarily generated and coordinated within the cortex, whereas sleep spindles are 12-16 Hz, waxing and waning oscillations that are initiated within the thalamus and regulated by thalamo-cortical circuits. In healthy subjects, these oscillations are thought to be responsible for the restorative aspects of sleep and have been increasingly shown to be involved in learning, memory and plasticity. Furthermore, deficits in sleep spindles and, to lesser extent, slow waves have been reported in both chronic schizophrenia (SCZ) and early course psychosis patients. In this article, we will first describe sleep spindle and slow wave characteristics, including their putative functional roles in the healthy brain. We will then review electrophysiological, genetic, and cognitive studies demonstrating spindle and slow wave impairments in SCZ and other psychotic disorders, with particularly emphasis on recent findings in early course patients. Finally, we will discuss how future work, including sleep studies in individuals at clinical high risk for psychosis, may help position spindles and slow waves as candidate biomarkers, as well as novel treatment targets, for SCZ and related psychotic disorders.
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