Evidence map›Paper›PMID 31753468›Full record

ArticleEnvironmental research2020

Effects of inhaled air pollution on markers of integrity, inflammation, and microbiota profiles of the intestines in Apolipoprotein E knockout mice.

Megan N Fitch, Danielle Phillippi, Yan Zhang, JoAnn Lucero, Ravi S Pandey, June Liu, Jeremy Brower, Michael S Allen, Matthew J Campen, Jacob D McDonald and 1 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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  17. Respiratory exposure to agricultural dust extract promotes increased intestinalAmerican journal of physiology. Gastrointestinal and liver physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Megan N FitchDepartment of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA.
Danielle PhillippiDepartment of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA.
Yan ZhangCenter for Medical Genetics, Institute of Molecular Medicine, University of North Texas Health Sciences Center, Fort Worth, TX 76107, USA.
JoAnn LuceroDepartment of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA.
Ravi S PandeyDepartment of Biological Sciences, University of North Texas, Denton, TX 76201, USA.
June LiuLovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87108, USA.
Jeremy BrowerLovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87108, USA.
Michael S AllenCenter for Medical Genetics, Institute of Molecular Medicine, University of North Texas Health Sciences Center, Fort Worth, TX 76107, USA.
Matthew J CampenCollege of Pharmacy, University of New Mexico, Albuquerque, NM, USA.
Jacob D McDonaldLovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87108, USA.
Amie K LundDepartment of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76201, USA. Electronic address: amie.lund@unt.edu.
University of North Texas · USMental Research Institute · USUniversity of New Mexico · USUniversity of North Texas Health Science Center · US

Funding

Mechanisms of Vascular Toxicity from Inhaled ToxicantsR01ES014639 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J · 2008 to 2023
$6.7M
The Renin-Angiotensin System in Air Pollution-Mediated Exacerbation of Obesity.R15ES026795 · NIEHS · UNIVERSITY OF NORTH TEXAS · PI LUND, AMIE KATHLEEN · 2017 to 2023
$874k
Enhancement of Coronary Constriction by Volatile Organic Air ToxicsR56ES014639 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J · 2013 to 2013
$148k
NIEHS NIH HHS R01 ES014639NIEHS NIH HHS R15 ES026795NIEHS NIH HHS R56 ES014639
6 · The paper itself

Abstract

Air pollution exposure is known to contribute to the progression of cardiovascular disease (CVD) and there is increasing evidence that dysbiosis of the gut microbiome may also play a role in the pathogenesis of CVD, including atherosclerosis. To date, the effects of inhaled air pollution mixtures on the intestinal epithelial barrier (IEB), and microbiota profiles are not well characterized, especially in susceptible individuals with comorbidity. Thus, we investigated the effects of inhaled ubiquitous air-pollutants, wood-smoke (WS) and mixed diesel and gasoline vehicle exhaust (MVE) on alterations in the expression of markers of integrity, inflammation, and microbiota profiles in the intestine of atherosclerotic Apolipoprotein E knockout (ApoE

Indexed as

Apolipoproteins EGastrointestinal MicrobiomeAir PollutantsAir PollutionAnimalsInflammationIntestinesMaleMiceMice, KnockoutRNA, Ribosomal, 16SVehicle EmissionsAir PollutantsApolipoproteins ERNA, Ribosomal, 16SVehicle EmissionsAir pollutionInflammationIntestine epithelial barrierMicrobiome

Identifiers

PMID31753468
PMCPMC6982581
OpenAlexW2983485988

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.