Evidence map›Paper›PMID 31753369›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2020

Nanoharvesting of bioactive materials from living plant cultures using engineered silica nanoparticles.

M Arif Khan, William T Wallace, Jatinder Sambi, Dennis Trent Rogers, John M Littleton, Stephen E Rankin, Barbara L Knutson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Effect of TiOPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

M Arif KhanDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
William T WallaceDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
Jatinder SambiNaprogenix Inc., Lexington, KY, USA.
Dennis Trent RogersNaprogenix Inc., Lexington, KY, USA.
John M LittletonNaprogenix Inc., Lexington, KY, USA.
Stephen E RankinDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address: stephen.rankin@uky.edu.
Barbara L KnutsonDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address: bknut2@uky.edu.
University of Kentucky · USNaprogenix (United States) · US

Funding

Harvesting specific plant metabolites from hairy root cultures using magnetized nanoparticlesR44AT008312 · NCCIH · NAPROGENIX, INC · PI LITTLETON, JOHN M. · 2017 to 2018
$1.0M
Harvesting specific plant metabolites from hairy root cultures using magnetized nR41AT008312 · NCCIH · NAPROGENIX, INC · PI LITTLETON, JOHN M. · 2014 to 2014
$190k
NCCIH NIH HHS R41 AT008312NCCIH NIH HHS R44 AT008312
6 · The paper itself

Abstract

Plant secondary metabolites are valuable therapeutics not readily synthesized by traditional chemistry techniques. Although their enrichment in plant cell cultures is possible following advances in biotechnology, conventional methods of recovery are destructive to the tissues. Nanoharvesting, in which nanoparticles are designed to bind and carry biomolecules out of living cells, offers continuous production of metabolites from plant cultures. Here, nanoharvesting of polyphenolic flavonoids, model plant-derived therapeutics, enriched in Solidago nemoralis hairy root cultures, is performed using engineered mesoporous silica nanoparticles (MSNPs, 165 nm diameter and 950 m

Indexed as

AnimalsBiotechnologyHumansMetal NanoparticlesNanostructuresPhytochemicalsSilicon DioxidePhytochemicalsSilicon DioxideCellular internalizationEngineered mesoporous silicaNanoharvestingNanoparticlesPhytotoxicityTherapeutics

Identifiers

PMID31753369
PMCPMC6935263
OpenAlexW2972605516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.