Evidence map›Paper›PMID 31752987›Full record

ArticleStem cell research & therapy2019

Allogeneic mesenchymal stem cells for treatment of severe burn injury.

Marc G Jeschke, Sarah Rehou, Matthew R McCann, Shahriar Shahrokhi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. The Effect of Mesenchymal Stem Cells on the Wound Infection.Current stem cell research & therapy · 2024
    Review
  8. Mesenchymal Stem Cells in Burn Wound Management.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Harnessing the Full Potential of Extracellular Vesicles as Drug Carriers.Current opinion in colloid & interface science · 2021
    Article
  15. Review
  16. Article
  17. The effect ofAging · 2020
    Article
  18. Burns in the Elderly: Potential Role of Stem Cells.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marc G JeschkeSunnybrook Research Institute, Toronto, Ontario, Canada. marc.jeschke@sunnybrook.ca.ORCID 0000-0003-0870-1664
Sarah RehouSunnybrook Research Institute, Toronto, Ontario, Canada.
Matthew R McCannSunnybrook Research Institute, Toronto, Ontario, Canada.
Shahriar ShahrokhiRoss Tilley Burn Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave. D7 04, Toronto, Ontario, M4N 3M5, Canada.

Funding

Hepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9M
CIHR 123336CIHR CMA151725NIH HHS R01GM087285
6 · The paper itself

Abstract

The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential.

Indexed as

BurnsMesenchymal Stem Cell TransplantationTrauma Severity IndicesWound HealingAdultAllograftsHumansMaleBurnsCell therapyMesenchymal stem cellsWound healing

Identifiers

PMID31752987
PMCPMC6869190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.