Evidence map›Paper›PMID 31752894›Full record

ReviewRespiratory research2019

Strategies for measuring airway mucus and mucins.

Kalina R Atanasova, Leah R Reznikov

Abstract readReview
In one paragraph

Review in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Review
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  5. Article
  6. Article
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  9. Article
  10. Review
  11. Article
  12. Article
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  14. Sensory artificial cilia for in situ monitoring of airway physiological properties.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kalina R AtanasovaDepartment of Physiological Sciences, University of Florida, 1333 Center Drive, PO Box 100144, Gainesville, FL, 32610, USA.
Leah R ReznikovDepartment of Physiological Sciences, University of Florida, 1333 Center Drive, PO Box 100144, Gainesville, FL, 32610, USA. leahreznikov@ufl.edu.ORCID http://orcid.org/0000-0002-4074-9070

Funding

Functional mapping of peripheral and central circuits for airway protection and breathingOT2OD023854 · OD · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2016 to 2020
$10.8M
Neural Pathogenesis of Airway Smooth Muscle Defects in Airway DiseaseR00HL119560 · NHLBI · UNIVERSITY OF FLORIDA · PI REZNIKOV, LEAH R · 2016 to 2018
$747k
Neural Pathogenesis of Airway Smooth Muscle Defects in Airway DiseaseK99HL119560 · NHLBI · UNIVERSITY OF IOWA · PI REZNIKOV, LEAH R · 2014 to 2015
$194k
National Institutes of Health (US) OD023854NHLBI NIH HHS HL119560NHLBI NIH HHS K99 HL119560NHLBI NIH HHS R00 HL119560NIH HHS OT2 OD023854
6 · The paper itself

Abstract

Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD). Studying mucus composition and its physical properties has therefore been of significant interest both clinically and scientifically. Yet, measuring mucus production, output, composition and transport presents several challenges. Here we summarize and discuss the advantages and limitations of several techniques from five broadly characterized strategies used to measure mucus secretion, composition and mucociliary transport, with an emphasis on the gel-forming mucins. Further, we summarize advances in the field, as well as suggest potential areas of improvement moving forward.

Indexed as

AnimalsBronchoscopyHumansMucinsMucociliary ClearanceMucusRespiration DisordersMucinsAirway mucusMucinsMucociliary transportTechniques

Identifiers

PMID31752894
PMCPMC6873701

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.