ArticleBMC complementary and alternative medicine2019
Cytotoxic activity of crude extracts from Datura stramonium's fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Isolation and characterization of an algicolous endophytic Mucor circinelloides from macroalga Colpomenia sinuosa as a promising source of bioactive metabolites for dermocosmetic applications.Scientific reports · 2026Article
- Metabolomic profile and bioactivity of fungal endophytes isolated from Crinum macowanii.BMC complementary medicine and therapies · 2025Article
- Antibacterial and anticancer properties of Solanum mauritianum fruit components analyzed using LC-QTOF-MS/MS.Scientific reports · 2025Article
- Bioactivity and metabolic profiling of crude extracts from endophytic bacteria linked toHeliyon · 2025Article
- Secretion of antifungal metabolites contributes to the antagonistic activity ofCurrent research in microbial sciences · 2025Article
- EndophyticInternational journal of molecular sciences · 2024Article
- Penicillides fromMolecules (Basel, Switzerland) · 2024Review
- Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of L-tyrosine and its biomedical applications.Microbial cell factories · 2023Article
- Cytotoxic Potential of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2022Article
- Article
- Assessment of Biological Activities of Fungal Endophytes Derived Bioactive Compounds Isolated fromJournal of fungi (Basel, Switzerland) · 2022Article
- Bioprospecting of endophytic microorganisms for bioactive compounds of therapeutic importance.Archives of microbiology · 2021Review
- Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals.Biotechnology reports (Amsterdam, Netherlands) · 2021Review
- Investigation of biological activity of soil fungal extracts and LC/MS-QTOF based metabolite profiling.Scientific reports · 2021Article
- Antibacterial and Anticancer Activity and Untargeted Secondary Metabolite Profiling of Crude Bacterial Endophyte Extracts fromInternational journal of microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundEndophytic fungi are a proven source of bioactive secondary metabolites that may provide lead compounds for novel drug discovery. In this study, crude extracts from fungal endophytes isolated from Datura stramonium were evaluated for cytotoxic activity on two human cancer cell lines.
methodsFungal endophytes were isolated from surface sterilized aerial parts of D. stramonium and identified using molecular, morphological and phylogenetic methods. Ethyl acetate crude extracts from these isolates were evaluated for cytotoxic activity on A549 lung carcinoma and UMG87 glioblastoma cell lines. Metabolite profiling was then performed by liquid chromatography coupled to quadrupole time-of-flight with tandem mass spectrometry (LC-QTOF-MS/MS) for the cytotoxic crude extract.
resultsEleven fungal endophytes were identified from D. stramonium. Significant cytotoxicity was only observed from the crude extract of Alternaria sp. KTDL7 on UMG87 glioblastoma cells (IC
conclusionThe findings in this study suggest that the crude extract of Alternaria sp. KTDL7 possesses compound(s) cytotoxic to glioblastoma multiforme cells. Future studies to isolate and characterize the cytotoxic compound(s) from this fungus could result in lead development of a fungal-based drug for glioblastoma multiforme treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.