Evidence map›Paper›PMID 31752807›Full record

ArticleBMC complementary and alternative medicine2019

Regulatory effect of Garidisan on dysbiosis of the gut microbiota in the mouse model of ulcerative colitis induced by dextran sulfate sodium.

Ling-Yan Pei, Yu-Shi Ke, Huan-Hu Zhao, Wei-Zhi Liu, Lin Wang, Chao Jia, Meng-Ni Shi, Qian-Hui Fu, Jian Cui, Shu-Chun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Review
  6. Mushroom polysaccharides fromFrontiers in pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ling-Yan PeiSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Yu-Shi KeCenter for Drug Evaluation, China Food and Drug Administration, Beijing, 100081, China.
Huan-Hu ZhaoSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Wei-Zhi LiuSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Lin WangDepartment of Histology and Embryology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Chao JiaSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Meng-Ni ShiSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Qian-Hui FuSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Jian CuiSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.
Shu-Chun LiSchool of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China. jason@muc.edu.cn.
Minzu University of China · CNNational Medical Products Administration · CNXinxiang Medical University · CN

Funding

the National Natural Science Foundation of China 81473796the National Natural Science Foundation of China 81774449
6 · The paper itself

Abstract

backgroundUlcerative colitis (UC) is a modern refractory disease, and its etiology has been difficult to discern. Studies have shown that UC is closely associated with the gut microbiota. Garidisan is composed of wild poppy and Artemisia frigida Willd and is commonly used for the treatment of UC in Inner Mongolia, China. In clinical settings, Garidisan has been found to treat UC effectively, with low recurrence. Previous studies have shown that Garidisan has a good therapeutic effect on mice with UC, but the therapeutic mechanism is still unclear. In this study, we investigated the regulatory effect of Garidisan on dysbiosis of the gut microbiota in a UC mouse model and explored the possible mechanism of the therapeutic effect of Garidisan on UC.

methodsThe UC mouse model was established by the dextran sulfate sodium (DSS) circulating free water drinking method, and the luminal contents were sampled under sterile conditions. High-throughput sequencing of the 16S rRNA gene V3 + V4 region of the luminal contents of the control group, model group, and Garidisan group was conducted, and clustering of operational taxonomic units (OTUs) and species annotation were performed. The differences in species composition and microbial community structure between individual groups of samples were analyzed using MetaStat, LefSe, rank sum test, and Bayesian causal network analysis.

resultsThe UC mouse model was successfully established and the sequencing results were of adequate quality. There were significant differences in the diversity of luminal contents between the control group, model group, and Garidisan group, and the differences between groups were greater than those within any group. The therapeutic effect of Garidisan on UC is attributed to the direct effect on the Lachnospiraceae family of bacteria.

conclusionGaridisan has a good regulatory effect on the gut microbiota, and Lachnospiraceae could be an important direct target of Garidisan for the treatment of UC.

Indexed as

AnimalsBacteriaColitis, UlcerativeDextran SulfateDisease Models, AnimalDysbiosisGastrointestinal MicrobiomeMaleMedicine, East Asian TraditionalMiceMice, Inbred C57BLPlant ExtractsDextran SulfatePlant ExtractsGut microbiotaMicrobiologyUlcerative colitis

Identifiers

PMID31752807
PMCPMC6873523
OpenAlexW2990252691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.