ArticleBMC pulmonary medicine2019
Clinical and radiographic predictors of successful therapeutic bronchoscopy for the relief of malignant central airway obstruction.
Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Applying the CHEST Guidelines for Management of Central Airway Obstruction.CHEST pulmonary · 2026Article
- Veno-Venous Extracorporeal Membrane Oxygenation for High-Risk Airway Interventions: A Safety-Net Hospital Case Series.Respirology case reports · 2026Article
- Outcomes and Prognostic Analysis of Therapeutic Bronchoscopy in Non-Small Cell Lung Cancer (NSCLC) Patients With Respiratory Failure Secondary to Malignant Central Airway Obstruction (MCAO).Pulmonary medicine · 2026Article
- A retrospective comparison of silicone and hybrid metal tracheobronchial Y stents.Journal of thoracic disease · 2025Article
- Interventional bronchoscopy in lung cancer treatment.Breathe (Sheffield, England) · 2024Review
- Tumor-Related Factors Affecting the Success of Interventional Bronchoscopy in Malignant Airway Obstructions.Archives of Iranian medicine · 2023Article
- Balloon Bronchoplasty for the Treatment of Bronchial Stenosis After Lung Transplantation: A Single-Center 10-Year Experience.Korean journal of radiology · 2023Article
- Early extracorporeal membrane oxygenation as bridge for central airway obstruction patients caused by neck and chest tumors to emergency surgery.Scientific reports · 2023Article
- Review of the clinical outcomes of therapeutic bronchoscopy for central airway obstruction.Mediastinum (Hong Kong, China) · 2023Review
- Therapeutic bronchoscopy in malignant central airway obstruction: is technical success always clinically relevant?Journal of thoracic disease · 2022Article
- Predictors of survival and technical success of bronchoscopic interventions in malignant airway obstruction.Journal of thoracic disease · 2021Article
- Tracheobronchial stents in patients with malignant airway disease: Finnish tertiary care experience.Interactive cardiovascular and thoracic surgery · 2021Article
- Feasibility and safety of a novel electrosurgery device as part of multi-modal bronchoscopic therapy for malignant central airway lesions.Journal of thoracic disease · 2021Article
- Long-term prognostic factors of clinical success after interventional bronchoscopy in patients with scarring central airway stenosis.BMC pulmonary medicine · 2021Article
- Analysis of Infusion Patterns of Propofol and Remifentanil During Rigid Bronchoscopy Under Total Intravenous Anesthesia.Anesthesiology and pain medicine · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalignant central airway obstruction (CAO) occurs in approximately 20-30% of patients with lung cancer and is associated with debilitating symptoms and poor prognosis. Multimodality therapeutic bronchoscopy can relieve malignant CAO, though carries risk. Evidence to guide clinicians regarding which patients may benefit from such interventions is sparse. We aimed to assess the clinical and radiographic predictors associated with therapeutic bronchoscopy success in relieving malignant CAO.
methodsWe reviewed all cases of therapeutic bronchoscopy performed for malignant CAO at our institution from January 2010-February 2017. Therapeutic bronchoscopy success was defined as establishing airway patency of > 50%. Patient demographics and baseline characteristics, oncology history, degree of airway obstruction, procedural interventions, and complications were compared between successful and unsuccessful groups. Univariate and multivariate logistic regression identified the significant clinical and radiographic predictors for therapeutic success. The corresponding simple and conditional odds ratio were calculated. A time-to-event analysis with Kaplan-Meier plots was performed to estimate overall survival.
resultsDuring the study period, 301 therapeutic bronchoscopies were performed; 44 (14.6%) were considered unsuccessful. Factors associated with success included never vs current smoking status (OR 5.36, 95% CI:1.45-19.74, p = 0.010), patent distal airway on CT imaging (OR 15.11, 95% CI:2.98-45.83, p < 0.0001) and patent distal airway visualized during bronchoscopy (OR 10.77, 95% CI:3.63-31.95, p < 0.001) in univariate analysis. Along with patent distal airway on CT imaging, increased time from radiographic finding to therapeutic bronchoscopy was associated with lower odds of success in multivariate analysis (OR 0.96, 95% CI:0.92-1.00, p = 0.048). Median survival was longer in the successful group (10.2 months, 95% CI:4.8-20.2) compared to the unsuccessful group (6.1 months, 95% CI:2.1-10.8, log rank p = 0.015).
conclusionsPredictors associated with successful therapeutic bronchoscopy for malignant CAO include distal patent airway visualized on CT scan and during bronchoscopy. Odds of success are higher in non-smokers, and with decreased time from radiographic finding of CAO to intervention.
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