ArticleGenes2019
SNP-Based Genetic Risk Score Modeling Suggests No Increased Genetic Susceptibility of the Roma Population to Type 2 Diabetes Mellitus.
Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Use of Genomic Information in Health Impact Assessment is Yet to Come: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Forensic height estimation using polygenic score in Korean population.Molecular genetics and genomics : MGG · 2024Article
- Clinical and Metabolic Particularities of a Roma Population with Diabetes-Considering Ethnic Disparities in Approaching Healthcare Management.Biomedicines · 2024Article
- Genetic risk scores: are they important for diabetes management? results from multiple cross-sectional studies.Diabetology & metabolic syndrome · 2023Article
- Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population.International journal of molecular sciences · 2023Article
- Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations.International journal of molecular sciences · 2023Article
- Review
- Genetic Susceptibility to Insulin Resistance and Its Association with Estimated Longevity in the Hungarian General and Roma Populations.Biomedicines · 2022Article
- Low prevalence of spectacle use in the Hungarian Roma population indicates unmet health needs.Scientific reports · 2022Article
- Polygenic risk for coronary artery disease in the Scottish and English population.BMC cardiovascular disorders · 2021Article
- CVD Risk Factors in the Ukrainian Roma and Meta-Analysis of Their Prevalence in Roma Populations Worldwide.Journal of personalized medicine · 2021Article
- Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?International journal of molecular sciences · 2021Review
- Comparative risk assessment for the development of cardiovascular diseases in the Hungarian general and Roma population.Scientific reports · 2021Article
- Changes in the Prevalence of Metabolic Syndrome and Its Components as Well as in Relevant Preventive Medication between 2006 and 2018 in the Northeast Hungarian Population.Journal of personalized medicine · 2021Article
- Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants.Frontiers in genetics · 2021Article
- A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors.Frontiers in endocrinology · 2021Article
- Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors.Journal of personalized medicine · 2020Article
- Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population.Molecular genetics & genomic medicine · 2020Article
- Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey.International journal of environmental research and public health · 2020Article
- The Roma Population Living in Segregated Settlements in Eastern Slovakia Has a Higher Prevalence of Metabolic Syndrome, Kidney Disease, Viral Hepatitis B and E, and Some Parasitic Diseases Compared to the Majority Population.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn a previous survey, an elevated fasting glucose level (FG) and/or known type 2 diabetes mellitus (T2DM) were significantly more frequent in the Roma population than in the Hungarian general population. We assessed whether the distribution of 16 single nucleotide polymorphisms (SNPs) with unequivocal effects on the development of T2DM contributes to this higher prevalence.
methodsGenetic risk scores, unweighted (GRS) and weighted (wGRS), were computed and compared between the study populations. Associations between GRSs and FG levels and T2DM status were investigated in separate and combined study populations.
resultsThe Hungarian general population carried a greater genetic risk for the development of T2DM (GRS
conclusionsThe higher prevalence of elevated FG and/or T2DM among Roma does not seem to be directly linked to their increased genetic load but rather to their environmental/cultural attributes. Interventions targeting T2DM prevention among Roma should focus on harmful environmental exposures related to their unhealthy lifestyle.
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