ArticleCells2019
Sex Differences in High Fat Diet-Induced Metabolic Alterations Correlate with Changes in the Modulation of GRK2 Levels.
Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of Sex, Smoking, and Physical Activity on Metabolic Syndrome Among Current Smokers: A Cross-Sectional Study from Taiwan.Healthcare (Basel, Switzerland) · 2025Article
- Glial fibrillary acidic protein vs. S100B to identify astrocytes impacted by sex and high fat diet.Physiology & behavior · 2025Article
- High-Fat Diet and Metabolic Diseases: A Comparative Analysis of Sex-Dependent Responses and Mechanisms.International journal of molecular sciences · 2025Review
- Does Sex Matter in Obesity-Induced Periodontal Inflammation in the SSDentistry journal · 2024Article
- Sex-based differences in short- and longer-term diet-induced metabolic heart disease.American journal of physiology. Heart and circulatory physiology · 2024Article
- MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.Scientific reports · 2023Article
- Article
- Role of Hypothalamic Reactive Astrocytes in Diet-Induced Obesity.Molecules and cells · 2022Review
- Sex hormones, intestinal inflammation, and the gut microbiome: Major influencers of the sexual dimorphisms in obesity.Frontiers in immunology · 2022Review
- Sexually Dimorphic Effects of a Western Diet on Brain Mitochondrial Bioenergetics and Neurocognitive Function.Nutrients · 2021Article
- HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.Journal of physiology and biochemistry · 2021Article
- Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice.International journal of molecular sciences · 2021Article
- Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones.Cells · 2021Article
- GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo.BMC biology · 2021Article
- Sex Differences in Metabolic Recuperation After Weight Loss in High Fat Diet-Induced Obese Mice.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A differential sex-related sensitivity has been reported in obesity and insulin resistance-related cardio-metabolic diseases, with a lower incidence of these pathologies being observed in young females when compared to age-matched males. However, such relative protection is lost with age. The mechanisms underlying such sex and age-related changes in the susceptibility to diabetes and obesity are not fully understood. Herein, we report that the relative protection that is displayed by young female mice, as compared to male littermates, against some of the metabolic alterations that are induced by feeding a high fat diet (HFD), correlates with a lower upregulation of the protein levels of G protein-coupled receptor kinase (GRK2), which is a key regulator of both insulin and G protein-coupled receptor signaling, in the liver and adipose tissue. Interestingly, when the HFD is initiated in middle-aged (32 weeks) female mice, these animals are no longer protected and display a more overt obese and insulin-resistant phenotype, along with a more evident increase in the GRK2 protein levels in metabolically relevant tissues in such conditions. Our data suggest that GRK2 dosage might be involved in the sex and age-biased sensitivity to insulin resistance-related pathologies.
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