Evidence map›Paper›PMID 31752295›Full record

ArticleNutrients2019

Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from

Aiste Jekabsone, Inga Sile, Andrea Cochis, Marina Makrecka-Kuka, Goda Laucaityte, Elina Makarova, Lia Rimondini, Rasa Bernotiene, Lina Raudone, Evelina Vedlugaite and 4 more

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05015387 (Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05015387 phase2completednot on this map

Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy: a Randomized Controlled Trial

TypeinterventionalSponsorLithuanian University of Health SciencesRan2019 to 2019Enrolled46ConditionsPeriodontitis, AdultArmsMinimally invasive non-surgical therapy, Subgingival application of collagen hydrogels with proanthocyanidins, Collection of saliva samples
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Discovery of Gingipains andFoods (Basel, Switzerland) · 2025
    Review
  8. Immunomodulatory Effects ofExpert reviews in molecular medicine · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Proanthocyanidins fromPlants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Aiste JekabsoneMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.ORCID 0000-0003-1527-6221
Inga SileLatvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV1006 Riga, Latvia.
Andrea CochisDepartment of Health Sciences, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0003-2455-8239
Marina Makrecka-KukaLatvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV1006 Riga, Latvia.ORCID 0000-0003-4549-1993
Goda LaucaityteMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.ORCID 0000-0003-3182-9754
Elina MakarovaLatvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV1006 Riga, Latvia.
Lia RimondiniDepartment of Health Sciences, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0002-7785-2282
Rasa BernotieneMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.
Lina RaudoneMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.
Evelina VedlugaiteClinic of dental and oral pathology, LSMU Hospital, Kaunas Clinics, Medical academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.
Rasa BanieneMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.
Alina SmalinskieneMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.
Nijole SavickieneMedical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.ORCID 0000-0001-9627-8231
Maija DambrovaLatvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV1006 Riga, Latvia.ORCID 0000-0002-1739-0928
Lithuanian University of Health Sciences · LTLatvijas Organiskās Sintēzes Institūts · LVUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITHospital of Lithuanian University of Health Sciences Kaunas Clinics · LT

Funding

Lietuvos Mokslo Taryba No. S-M-ERA.NET-17-2Ministero dell'Istruzione, dell'Università e della Ricerca S-M-ERA.NET-17-2State Education Development Agency Republic of Latvia No. S-M-ERA.NET-17-2
6 · The paper itself

Abstract

The study explores antibacterial, antiinflammatory and cytoprotective capacity of

Indexed as

PelargoniumPlant RootsAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsApoptosisBacteriaCells, CulturedFibroblastsGingivaHumansInflammation MediatorsMacrophagesMaleMice, Inbred C57BLNecrosisAnti-Bacterial AgentsAnti-Inflammatory AgentsInflammation MediatorsPlant ExtractsProanthocyanidinsbacteriotoxicityfibroblastsgene expressioninflammatory cytokinesleukocytesmacrophagesPelargonium sidoides DC root extractperiodontitisproanthocyanidins

Identifiers

PMID31752295
PMCPMC6893413
OpenAlexW2977456584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.